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Why Don't NSAIDs Work for Fibromyalgia Pain?

By Adrienne Dellwo, About.com

Updated July 03, 2008

About.com Health's Disease and Condition content is reviewed by the Medical Review Board

Question: Why Don't NSAIDs Work for Fibromyalgia Pain?
Why don't pain relievers like Motrin, Advil and Aleve work against the pain of fibromyalgia?
Answer:

It's a common misconception that fibromyalgia is an inflammatory or rheumatological condition, but it is not. While researchers still have many theories about the mechanisms behind fibromyalgia, many of them now believe the condition is more neurologically based.

Aleve (naproxen sodium) and ibuprofen-based drugs (Motrin, Advil) are non-steroidal anti-inflammatory drugs (NSAIDs), and are most effective against pain that accompanies inflammation. They're generally not as effective against other types of pain, especially when pain is severe.

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