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Melatonin for Fibromyalgia & Chronic Fatigue Syndrome

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Updated December 11, 2012

Written or reviewed by a board-certified physician. See About.com's Medical Review Board.

Melatonin's Medical Uses:

Melatonin supplements are best known as sleep aids. The supplements contain a synthetic form of a hormone/neurotransmitter that your body produces to help regulate the sleep cycle and perform a variety of other functions.

While not all of the benefits attributed to melatonin supplements are supported by solid research, melatonin is believed to:

  • Alleviate jet lag
  • Improve the sleep disorder called delayed sleep phase syndrome
  • Treat insomnia in the elderly
  • Improve sleep quality
  • Have anti-inflammatory and antioxidant properties
  • Calm anxiety
  • Lower pain levels
  • Enhance cognitive function
  • Improve glycemic control in some diabetes patients
  • Help treat menopause, irritable bowel syndrome and seasonal affective disorder

How Melatonin Works:

In a healthy person, natural melatonin levels rise as it gets dark outside, and that helps make you tired. Your body uses serotonin to make melatonin. People with fibromyalgia and chronic fatigue syndrome are believed to have dysfunctional serotonin metabolism.

Does that mean these conditions are linked to melatonin problems as well? It actually may not, but research on that isn't totally clear.

Melatonin for Fibromyalgia:

Early research on melatonin for fibromyalgia suggested that people with this condition have lower night-time levels of melatonin, which may make it hard to fall asleep and leave you tired the next day. That lead to a belief that melatonin supplements may be an effective treatment.

However, in later research, melatonin levels were normal or even increased compared to healthy controls. It is not surprising then that research on effectiveness of melatonin supplementation is split as to whether it helps relieve fibromyalgia symptoms. A 2002 study showed that it improved sleep, pain and tender-point count while other studies show no significant improvement.

Fibromyalgia research is plagued with this kind of inconsistency, which complicates the treatment process. And it's not just research – many people with fibromyalgia experiment with melatonin. Some report that it works well for helping them sleep, while others say it has no effect whatsoever.

Melatonin for Chronic Fatigue Syndrome:

According to research, chronic fatigue syndrome doesn't appear to be linked to low melatonin levels. In fact, one study suggested that adolescents with this condition may actually have elevated levels. Several studies state that there's no indication for melatonin in chronic fatigue syndrome.

An exception is a study on people with chronic fatigue syndrome who also had delayed nocturnal melatonin secretion, which might cause difficulty falling asleep. In this subgroup, three months of treatment with melatonin was linked to improvement in fatigue, concentration, motivation and activity.

As with fibromyalgia, you can find people with chronic fatigue syndrome who report improvement with melatonin as well as those who say it didn't help.

Melatonin Dosage:

You can buy melatonin supplements over-the-counter in dosages generally ranging from 3 micrograms to 5 milligrams. Other dosages may be available as well.

Melatonin Side Effects:

We don't have any evidence of major toxicities associated with melatonin, even at high doses.

Minor side effects noted in studies include:

  • Headache
  • Short-term depression
  • Dizziness
  • Nausea
  • Poor urine control
  • In psychiatric patients, worsening depression

If melatonin is taken during the day, it may cause excessive sleepiness and impaired motor control.

We don't currently have information about melatonin's safety during pregnancy and breastfeeding.

Caffeine and the prescription antidepressant fluvoxamine may inhibit the metabolism of melatonin. Melatonin may dampen the effects of the calcium-channel blocker nifedipine, and it may increase the risk of bleeding for people taking warfarin.

Always be sure to include your doctor in decisions about supplementation. Your pharmacist can help you identify potentially dangerous interactions with drugs or other supplements you may be taking.

Also See:

Sources:

Citera G, et al. Clinical rheumatology. 2000;19(1):9-13. The effect of melatonin in patients with fibromyalgia: a pilot study.

Cleare AJ. Endocrine reviews. 2003 Apr;24(2):236-52. The neuroendocrinology of chronic fatigue syndrome.

Dauvillier Y, Touchon J. Neurophysiologie Clinique. [Article in French – abstract referenced.] Sleep in fibromyalgia: review of clinical and polysomnographic data.

Graw P, et al. Behavioral brain research. 2001;121(1-2):167-172. Early morning melatonin administration impairs psychomotor vigilance.

Knook L, et al. The journal of clinical endocrinology and metabolism. High nocturnal melatonin in adolescents with chronic fatigue syndrome.

Korszun A, et al. Journal of rheumatology. 1999 Dec;26(12):2675-80. Melatonin levels in women with fibromyalgia and chronic fatigue syndrome.

Mahdi AA, et al. Indian journal of biochemistry & biophysics. 2011 Apr;48(2):82-7. Abnormality of circadian rhythm of serum melatonin and other biochemical parameters in fibromyalgia syndrome.

Reiter RJ, Acuna-Castroviejo D, Tan DX. Current pain and headache reports. 2007 Oct;11(5):339-42. Melatonin therapy in fibromyalgia.

Sanchez-Barcelo EJ, et al. Current medicinal chemistry. 2010;17(19):2070-95. Clinical uses of melatonin: evaluation of human trials.

Senel K, et al. Rheumatology international. 2011 Dec 23. Melatonin levels in permenopausal women with fibromyalgia syndrome.

van Heukelom RO, et al. European journal of neurology. 2006 Jan;13(1):55-60. Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion.

Web SM, Puig-Domingo M. Clinical endocrinology. 1995;42(3):221-234. Role of melatonin in health and disease.

Wikner J, et al. Clinical endocrinology. 1998 Aug;49(2):179-83. Fibromyalgia—a syndrome associated with decreased nocturnal melatonin secretion.

Wilhelmsen M, et al. Journal of pineal research. 2011 Oct;51(3):270-7. doi: 10.1111/j.1600-079X.2011.00895.x. Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies.

Williams G, et al. European journal of clinical investigation. Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy.

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