To form your plan of attack, think about how you function best. Does driving stress you out, or is your car a welcome place of solitude between noisy stores? Do you like one-stop shopping, or are you overwhelmed by large stores? How far can you walk without resting, or in a single day?
Take your answers to those questions and decide where you want to shop. Make sure you know how to get there and how to get between stores if you're going to multiple locations. (I always keep a phone book in my car so I can check the map or call for directions. Others like to use mobile devices to get the information they need on the go.)
