Malaise is a vague feeling of body discomfort or a general feeling of being unwell, much like you feel when you're coming down with a cold or the flu.
Post-exertional malaise is a period of intense exhaustion and other ME/CFS symptoms that lasts for more than 24 hours following physical exertion. This symptom is a hallmark of chronic fatigue syndrome (CFS or ME/CFS) and causes detectable differences in the blood that are being studied as a possible diagnostic marker.

