Researchers say that the vast majority of studies examined showed an association between fibromyalgia and depression. (While all chronic disease can lead to depression, rates tend to be higher in fibromyalgia than in similarly debilitating conditions, such as rheumatoid arthritis.)
The review concludes that the multiple common physiological characteristics shared by depression and fibromyalgia are responsible for the large overlap. Researchers say this provides a framework for understanding the relationship and also sheds light on appropriate treatment avenues.
One of the key commonalities between the two conditions is neurotransmitter dysregulation.
For a look at other factors that likely contribute to depression in fibromyalgia, as well as the treatment option being promoted by one medical organization, see: Therapy or Pills for Depression in Fibromyalgia?