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Adrienne Dellwo

New Drug Formulation for Fibromyalgia Moves Forward

By April 9, 2012

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Research Brief

An old drug in a new form is moving forward through trials, and the manufacturer hopes it will eventually be approved for treating fibromyalgia.

TONIX Pharmaceticals has announced that it's completed an early phase of testing for what's being called TNX-102. (This name is a research designation and, if the drug is successful, will eventually be replaced.)

TNX-102 is a combination of:

  • Very Low-Dose Cyclobenzaprine: the drug in the muscle relaxant Flexeril, which a recent study suggests may improve sleep and other core symptoms of fibromyalgia when taken at bedtime in very low doses;
  • Lipids: naturally occurring substances in your cells that help with energy storage, signaling, and the structure of membranes.

The TONIX study involved 30 healthy subjects who took the medication at bedtime. It was meant only to gauge how the body processed the new formulation. Noting no severe or unexpected side effects, the company now plans to move forward with further development and testing.

In a press release, Chairman and President of TONIX said, "The results of this study provide us with valuable insights which will enable us to further advance our development programs targeting fibromyalgia and other challenging disorders of the central nervous system.... We are developing TNX-102 to be a fundamental advance in sleep hygiene and pain management and to be safer and more effective than currently available treatments."

The press release points out that disturbed sleep is a core feature of fibromyalgia and yet no "bedtime medication" is approved for it.

The road to FDA approval is long and complicated, meaning that even if all goes well, TNX-102 is unlikely to be on the market for several years.

However, cyclobenzaprine already is prescribed off-label for some people with fibromyalgia, especially when muscle spasms are a serious problem.

Have you taken cyclobenzaprine? Has it helped with your symptoms? Does it improve your sleep? Leave your comments below!


Photo Adam Gault/Getty Images

April 9, 2012 at 9:05 pm
(1) Patty says:

Better come up with something stronger than that. What a joke.

April 9, 2012 at 9:16 pm
(2) Lynette says:

I suffer from fibromyalgia, chronic fatigue, and unspecified myopathy. 2 1/2 months ago I was put on 10 mg of Flexeril at bedtime due to muscle spasms in my neck and also in an attempt to help me sleep since by body had become immune to all the sleep aides. I now get about 6 hours of sleep a night-not continous, but that is by far better than the 2-3 that I was getting before that weren’t continous. Also during this 2 1/2 months, I have not had a Fibromyalgia flare up! (crossing everything I’ve got!!!) Fatigue is still significant.

April 10, 2012 at 1:43 am
(3) Kay says:

One of the problems with flexeril (even in low doses) is constipation and in FMS patients it can be 10 times as bad which can cause cramping, muscle spasms & pain in the guts, lower back, etc. Don’t think it’s going to be much good but since most of us are desparate for new meds we’ll try it…

April 10, 2012 at 11:31 am
(4) jmar says:

Have taken flexeril. Gives anxiety attacks and muscle spasms. Just makes me feel drunk. How can they even approve a drug for something that causes what it is supposed to help?!! Idiots!

April 10, 2012 at 2:05 pm
(5) Glen says:

I’m not sure if my experience is relevant because I seem to be hyper-sensitive to the drowsy effects of meds.

I sometimes take 1/3 of a 10 mg Flexeril at bedtime and this is enough to send me into a very sound sleep.

April 10, 2012 at 2:10 pm
(6) FMMama-Anne Arato says:

I take cyclobenzaprine for lower back muscle spasms, and it helps into the next day for that, but I always feel tired and hung over. It does produce much better sleep in me too, even at a very low dose-like a third of a 5 mg tab. Maybe it can help in a combination as you plan to release it.

April 10, 2012 at 2:12 pm
(7) Karen says:

I take generic cyclobenzaprine at bedtime along with Lyrica and I now get about 6 hrs sleep vs the 2-3 I was getting. I will also take it during the day if I am having alot of muscle spasms.

April 10, 2012 at 2:22 pm
(8) Aundrea Hornback says:

I was prescribed Flexeril, at 10 mg and 5 mg and it did absolutely NOTHING to help me, I still had severe muscle spasms, did not sleep any better or any more. I agree with they better try something stronger. Flexeril is a joke

April 10, 2012 at 2:39 pm
(9) Shelley says:

I take Lavo-Carb at bed time to help with leg spasms and it helps a LOT. When you stop the leg spasms it helps me sleep. Not a “cure all” by any means but it helps. :)

April 10, 2012 at 2:47 pm
(10) Jaime says:

This might be a better option to traditional Flexeril for us. It says that there is a Lipid component to this, so that makes this look very promising actually! Not sure what the Lipid part is for, though. But I know that either it can aide in delivering the med more smoothly so we don’t have such negative reactions, or perhaps they are working on our imbalance of Omegas or something along that line? In the perfectly ideal world, it would be for both!!! No, this isn’t the “wonder drug” obviously… but as we all have learned one little step in the right direction is a beautiful thing!!!

April 10, 2012 at 4:09 pm
(11) Mia says:

I’m not hopeful that I will see a cure or even a medication that can give much relief in my lifetime (just under 50). Instead I am aiming at doing what I can naturally. Removing most gluten from my diet has helped some with fatigue and a little with pain. Also taking loads of vitamins, herbals and SUPER amounts of antioxidants…..that’s where I saw the biggest improvement. Another thing that helped was doing a cleanse and removing toxins from my system. Our guts are notorious for having issues because we are not eliminating everything. Cleaning that out helps greatly. And I stay that way by taking a Probiotic, Prebiotic and also Magnesium daily. Check with your doctors or pharmacist to make sure nothing interferes with any rx medications you are taking.

I had to go this route for me because of my depression. I feel better when I feel like I’m in charge of my health. With having had breast cancer, hysterectomy, shattered disc in my neck that was removed and a fusion done resulting in 2 more herniated inoperable discs, the fibro/cfs, hypo-thyroid, chronic pain etc etc….I just got sick of doctors shoving meds at me with no improvement and worrying what the new med would do to me.

April 10, 2012 at 4:10 pm
(12) Michelle Reed says:

I have fibro and have taken flexeril. I did sleep better but it wasn’t a restful sleep. As for muscle spasms I used to get them bad in my legs to where they would draw up against me and you couldn’t pull them down. I fixed that with a bar of soap. Put it between the fitted sheet and the mattress and it does work. At least it works wonders for me.

April 10, 2012 at 5:03 pm
(13) Jacinda says:

flexoril was a wonder drug for me, until suddenly without warning it quit working. :(

April 10, 2012 at 5:24 pm
(14) Charlotte Gregg says:

Yes I did take this Flexeril for awful muscle cramps in my legs and hips. I took the cramps away, and it did help me sleep, Couldn’t take it during the day if I had to drive because it made me sleepy.. I’m now on Cymbalta and Neurontin, they help bust still get cramps and pain, not quit as bad as years ago… Diagnosed in 5/1987 with Fibromyalgia. People and some doctor’s don’t understand how a person with this condition feels. I would like to see the new drug come on the market for this condition…just so tired of feeling out or it, sleepy, tired, fibro fog, just down right awful all the time…
Thanks for this information.

April 10, 2012 at 5:34 pm
(15) FibroTalk says:

So, they are going to give us a VERY LOW dose of Flexeril, and mix it with some lipids (IMO just to make it a new drug). Then they will probably charge up the — for it.
Really???? Gee, thanks….
Regular doses of Flexeril barely do anything for most FM sufferers I know.
It doesn’t even seem like much of a try to me. Maybe I’m wrong….

April 10, 2012 at 5:58 pm
(16) anon says:

What a joke. Flexeril and lipids? Come on. Thanks for doing everything but taking us seriously.

April 10, 2012 at 6:01 pm
(17) Coyotes Rock says:

I take it. It does help me. I take Gabapentin also. These are the only 2 drugs I have for my Fibro. I take Flexeril 10mg. I can take up to 20 mg 3 x a day. I rarely take it more than once a day. I usually take it at bedtime and it helps. It does not take away the pain. It helps my muscle relax. Pain, now that is another thing.

April 10, 2012 at 6:03 pm
(18) Leigh says:

I was prescribed flexeril 10mg up to twice a day for spams and it really does nothing. I do not think this “new formulation” is going to do much for us fm and cfs sufferers. :(

April 10, 2012 at 6:04 pm
(19) Mackenzie Artz says:

10 mg of Flexeril does nothing for me. :(

April 10, 2012 at 6:05 pm
(20) Jennifer says:

This will not work!!! I know so m&y people who have taken flexeril and lipids just as I have and made things worse!!! Sorry, this is not going to work! It makes it to where I am un able to urinate and my cfs is worse!!! Opiates work better but I believe another muscle spasm drug should coincide with it. Come On seriously we are in dire need of help!!! Go back in your think tank and keep trying!!! Nothing that has been perscribed for me has worked… Only relief I’ve ever got was pain killers and soma and lipids, but I still had very bad weeks where I am constricted to my bed or couch!!!! These are veryirritating depressing auto immune diseases!!! : (

April 10, 2012 at 6:11 pm
(21) Dana says:

I take 10mg of Flexeril and 20mg of Elavil at bedtime and sleep 8-10 hours. The combination of the two drugs puts me into a very deep sleep. A freight train could go through the bedroom and I wouldn’t know it. I am groggy in the morning, very stiff, and usually have a low backache, but those symptoms eventually wear off within a couple of hours. The combination has helped me have continuous sleep and because of that I’m able to deal with the daily pain levels better than if I was trying to do without any sleep.

April 10, 2012 at 6:17 pm
(22) Cathy says:

I didn’t do well on Flexeril, though I did try to take it during the day which made me drowsy and useless. Taking just a small dose at night might be helpful. I was on a drug similar to Elavil at bedtime and it helped with sleep but my memory was terrible afterwards! Like another one of the posters, I’m really sensitive to most meds so sometimes the side effects are as bad or worse than the intended benefits. (Another vote for holistic remedies like acupuncture, etc…)

April 10, 2012 at 6:23 pm
(23) Pam says:

Really?? This is what the hope for my future is?? I was on Flexeril so many times, by so many docs over the past 15 years or so. I thought we were closer to hope than this. Wow! It’s like taking aspirin when you are in the more advanced stages of Fibro and CFS. Grrrrr. I’ve waited 20 years for this???? Very disappointed :(

April 10, 2012 at 6:27 pm
(24) mary says:

flexaril does nothing even taking 20 mgs my Dr says that should knock me out. NOTHING. I take cymbaltha, lyerica, elavil, flexaril. I get more pain relief from the elavil.
Someone please come up with something for the muscle spasms.

April 10, 2012 at 6:40 pm
(25) sjb says:

If i take flexeral it gives me nitemares for one. I go into a deep sleep thru part of the nite. I build up a tolerance for it just like other meds in a few days, so I have to take it for a few days quit take benedryl for a few days, meletonin for a few days i can go back now and take flexeril for a few days I cant continue taking one med for long. Sounds strange but thats how my fibro works. I really dont like the nitemares flexeral causes as a side effect. And I dont take a whole pill if i do i have hung over feelings the next day.

April 10, 2012 at 6:41 pm
(26) Andy says:

I have used Flexaril in patients for several years but I find it useless for muscle spasms. I give it at night, usually with either Neurontin or Lyrica and some sort of opioid analgesic such as Ultram, Lorcet or sometimes Percocet. Getting the pain level down helps you sleep much better, at least that has been what treating MANY FMS patients has taught me.

April 10, 2012 at 6:43 pm
(27) Judy Thomas says:

I take 20-4-mg. with my sleep med Halcion and still only get 6 hours! But that is more than the 2 hrs. I got for over a year.

April 10, 2012 at 7:06 pm
(28) Nena says:

I typically only take flexeril at night and only if I’m having bad cramps in my legs and feet or a lot of pain in my neck and shoulders. It does allow me to sleep. I can see where it might be helpful for sleep because if I take it in the daytime I feel very druggy.

April 10, 2012 at 7:10 pm
(29) Eelia says:

I took this until it stopped working all together. I don’t see how adding a lipid will magically make it work again!
I have been wrestling with the fact that the future of Fibromyalgia medicine is bleak. I would love to try the many suggested natural therapies out there but I can’t afford that on disability. I figure I will not have a quality of life for any length of time since most medications I take that work at first, stop working within a year. I don’t know if that is normal but I find myself becoming immune to the drugs given to me.
There is no magic pill to cure Fibro this is something that has to be attacked from every angle.

April 10, 2012 at 7:16 pm
(30) libramoondance says:

Flexaril was never strong enough…I take zanaflex(tizanadine) at night for spasms and it has been wonderful in allowing me a restful sleep cycle!

April 10, 2012 at 7:16 pm
(31) Patti says:

I take Flexiral every night at bed time. I wouldnt be able to sleep without it. In the beginning you tend wake up groggy but after a while that goes away. Been on it 2+ years after not being able to sleep ! I had RLS extremely bad so I take amitriplyne too at night. I recommend it for anyone who has issues sleeping cause of Fibro.

April 10, 2012 at 7:34 pm
(32) Theresa says:

I take 20 mg every night, it does help, but not much. I dont have medical insurance and this is a cheap drug so I use it, but I would sure like to be able to try other things.

April 10, 2012 at 7:34 pm
(33) Robin says:

I used to take flexeril but didnt help much. At bedtime, i take lyrica, cymbalta,zanaflex for muscles, halcion to get me asleep and 2mg klonopin with it to help me stay asleep. So between the zanaflex, halcion and klonopin, i sleep pretty good but not necessarily all nite. i wake with hurting joints from sleeping so still.

April 10, 2012 at 7:42 pm
(34) ckmd says:

Ultram is NOT an opioid!!

April 10, 2012 at 8:47 pm
(35) ZBT says:

I am feeling very fortunate indeed. My chiropractor has worked wonders for keeping me able to function…even after 25+ years of fibromyalgia. I do struggle to get restful sleep…but find that “sleep meds” tend to leave me feeling hung over. So I am getting by with low doses of nortriptyline, Lexapro, & zonisamide. Vitamin D has helped some…I think.

Have not tried Flexoril in many years. As I recall, it made me very sleepy, but I did not feel rested upon awakening.

April 10, 2012 at 8:48 pm
(36) Jackie says:

I take Flexerill, two 10 Mg. pills every night. While I do awake somewhat groggy, it absolutely helps me sleep. However, it does nothing for muscle spasms. Still, I am thankful for the help it does give. I went three years with nothing and my life was bell. I also take Ultram, two tabs twice daily, and Cymbalta – 60mg. On nights when sleep just won’t come, I take a cocktail of two Benedryl, two Flexerill and two Ultram. If I don’t sleep after that…it’s just not gonna happen.

April 10, 2012 at 8:54 pm
(37) kkfullard says:

Flexeril does absolutely nothing for me. I take zanaflex for my muscle spasms, which is a lot stronger than Flexeril. Hopefully they can come up with something stronger to help with my symptoms.

April 10, 2012 at 9:01 pm
(38) Marlene says:

I can’t sleep without Flexeril. I take it at night with Cymbalta, alprazolam, and 2000 iu of Vitamin D. If I don’t take it I get muscle cramps and whole body jerks that keep me from falling asleep. With this combo I get at least 6 hours with dreams. What sucks is that nothing works for everyone.

April 10, 2012 at 9:06 pm
(39) jackie says:

I take Flexiril at bedtime, 10mg, on occasion, I dont take it every night because it affects me so the morning. I am a zombie, takes 3-5 hours to wake up. And the point of taking it is to help with sleep but I wake several times during the night in pain. It does lessen the cramps and spasms, so when they are severe enough I do take it.

April 10, 2012 at 10:28 pm
(40) Shannon L says:

I already take Amrix 30mg in the evening. AMRIX is extended release Flexeril and has helped me the most with my fibro. I have taken it for 4 years now. My muscles were so twitchy, and they would jerk my extremities so badly at time’s. You could liteally see them ‘crawl’ under my skin. I slept much better after taking even the 15mg but, am now on 30mg. So, what is the difference in Tonix? Doesn’t sound like it will do anything for those of us who have severe cases. I take melatonin 3mg about an hour before I want to go to sleep…..it’s natural to our bodies. I am all for as much ‘natural’ as possible.

April 11, 2012 at 12:15 am
(41) Steve M says:

I take Flexeril and Neurontin for my Fibromyalgia; other medications had too many drastic side effects with little benefit. I do find the Neurontin helpful, but the Flexeril doesn’t seem to do too much for me. Everyone I’ve spoken to who has taken it always told me how one pill knocked them right out, but I’ve never experienced any kind of drowsiness from it whatsoever. Taking 30mg a day (10mg 3 times a day) doesn’t seem to phase me, and while I’ve not experienced any negative side effects, I question what little, if any, benefit it is giving on top of the Neurontin.

April 11, 2012 at 10:19 am
(42) Kris says:

I take Baclofen , it does help me sleep, but don’t think it really helps the muscle pain and spasm, I think it relaxes them and might actually by relaxing them make it worse. All I know though this does help me sleep, but I have a hard time getting up in the morning.

April 11, 2012 at 10:35 am
(43) Mendy Clarke says:

Unfortunately, Flexeril gives me night terrors…can’t take this drug even if they DO figure it out…hope it works for some of you…

April 11, 2012 at 2:50 pm
(44) Pam says:

So far there is not one thing that has worked for me. I have been on Lyrica, Neurotin, Flexeril, Cymbalta, some kind of arthritis pills, sleeping pills, percacet, vicodin, and steroids. Not one, not one has worked. So keep trying people!

April 12, 2012 at 10:44 am
(45) Andrew says:

I’ve been on flexeril many times for my fibro and muscle spasms. Too much drowsy and not enough relief! I now take robaxin 750 two twice a day sometimes 3x’s. No drowsy and feel great. Also trazadone 100mg to sleep. Best combo for many years!

April 12, 2012 at 9:42 pm
(46) Brittany says:

I only take it when I’m in a flare that is keeping me from sleeping. It relaxes me ENOUGH and makes me drowsy so I nod off easier. The little bit of groggy in the morning is worth it to get even a little more sleep than if I hadn’t taken it.

April 13, 2012 at 3:36 pm
(47) Donna says:

I have been prescribed Flexeril to help deal with pain associated with muscle spasticity. In some situations it helps; but, it makes me sleepy. However, I don’t have any better quality of sleep with Flexeril. I still wake up feeling drugged and like I’ve been awake all night.

April 13, 2012 at 3:45 pm
(48) Cheryl says:

I have taken Flexeril but I am zoned out the next day!!! Not worth it to me. I take 500 mg. of magnesium a day and have notice a significant improvement with spasms & muscle twitches.

April 13, 2012 at 3:59 pm
(49) barb Fiveash says:

I have found Tryptophan helps me sleep. See Wong.

April 13, 2012 at 4:08 pm
(50) barb quester says:

i take a combination of neurontin which was originaly prescribed for buring feet, soma (flexeril didn’t seem to be strong enough), and hydrocodone 10/325. i have pretty bad osteoarthritis, along with fm and cfs. we just did an mri on C5/6 and found that this damage is contributing to my pain in my arms and hands. dr also added lyrica to see if that would help.
it is amazing that when we all were young we didn’t even want to take an aspirin and now here we are taking so many drugs we can’t keep track!

thank you adrienne for all you do for us.

April 13, 2012 at 4:12 pm
(51) Vandamir says:

I’m very encouraged by this. I’ve been taking Flexeril for my Fibromyalgia since I was diagnosed in 1993. It’s the only medication that’s worked for me and allows me to get the stage 4 sleep my body can’t get without drug intervention. My pain symptoms were completely under control with Flexeril and lifestyle changes alone until 2008 when a huge mold event in my building made my health issues snowball out of control. I’m now taking Flexeril along with Melatonin, Magnesium and 5HTP and my Fibromyalgia pain is again controlled. Other health issues that arose from the mold still plague me but not living with daily FMS pain is a huge relief.

April 13, 2012 at 5:12 pm
(52) Lois says:

I have to Laugh because Flexeril was the first medication used to try to help get me some sleep back in 1996. All it did was make me feel like I needed to sleep but all I could do was sit around like a lump on a log. Not fun at all.

This drug will never be used by me again. As far as I am concerned they are wasting good research money!!

Thankfully I have meds that do help me sleep now. Trazodone for sleep, Clonazepam for restless muscles. It takes the combination to work.

April 13, 2012 at 5:54 pm
(53) Bobbie says:

I have taken the generic for Flexaril for a number of years and it does help me very much! I do not take it every night but when my pain gets to severe I take half to a whole 10 mg. with my pain med before bedtime and most times when I wake up I find it has broken the cycle of spiraling out of control pain that would follow without it. My doc also says it is better for sleep as it doesn’t prevent REM cycle like sleeping meds do so sleep is better quality. At first I expected too much from the results and set myself up for dissapointment! I’m glad I didn’t give up on it and have learned it helps me better than I realized, just wasn’t immediate.

April 13, 2012 at 6:25 pm
(54) Mummylady says:

Flexeril made me gain weight, I had a serious personality change, and always made me feel hung over, and did little or nothing for helping me sleep. I now tkae a low does of tranxene, citalopram and a methocarbomol and that has been working as far as sleep goes, but it does give me VERY vivid dreams.

April 13, 2012 at 6:55 pm
(55) linda morgan says:

I was taking flexerol for a year or more. I ran out while on vacation so didn’t take it for about 3days. While I took it I would wake up in the morning saying I feel lime a truck hit me I hurt all over. Those few days I didn’t take it I didn’t feel like I was hit buy a truck. Told my Dr. She said don t take it anymore. Couldn’t believe I took that for so long.

I would also like to know how many people have hoshimotos desease. I was diagnosed with it over 40 years ago. I just learner it is a auto ammune disorder. There is a lot of people diagnosed with. A thyroid problem. How many with hoshimotos. I have been taking medication for it. The indocrinologist says never take the generic. They’ll give me a tx for synthroid one time then next time you get it filled they give you generic. So you go back to the Dr they write a new tx saying don’t use generic. It’always goes back to generic. The Dr.s don’t really tell you how to take the medication either. I took it for about 10 yrs went to a different pharmacy they said name sure you don’t take them at night cause your on dice a high dose you won’t sleep. I had been having problems sleeping g told the Dr they gave me sleeping pills that I also are hooked on now. Any body else have problems Bering information on a diagnosis or directions on how to take there mere. I am really getting frustrated.

April 13, 2012 at 8:00 pm
(56) ddebru01 says:

I’ve been on Flexeril for about 5 yrs now. At first it was for RLS and before bed. Over the last 4 yrs my dosage has been increased to 4-10 mgs/day for the RLS, Myofascial and severe Fibro. One in the morning, one at evening and 2 before bed. It has improved my RLS, Fibro, sleep and muscle spasms tremendously. It has been a huge life saver for me. My body has gradually built a tolerance to it and I don’t have any drowsiness from it anymore. I believe it would help many fibro patients as it has me.

April 13, 2012 at 9:10 pm
(57) Mary says:

Flexeril did nothing for me other make me horribly depressed. I also felt very drugged the next day. I take neurontin, soma, tramadol and Klonopin now, also have a CPAP for the sleep apnea. Still get leg cramps and very stiff in the morning, takes me a little while to get my legs moving. Would never try Flexeril again!!

April 13, 2012 at 11:15 pm
(58) Mitzie says:

I take 10mg of Flexeril 3 times a day. Without it I have unbearable muscle spasms. I know it can be very frustrating trying to find the right cocktail to treat our myriad of symptoms. Try to focus on the good. Never give up hope!

April 14, 2012 at 12:13 am
(59) Lorilyn says:

Flexeril has never done one thing for me. It never worked for whip-lashes, nor relaxing my (now don’t laugh) my butt muscles. Those muscles tighten up so tight on me, I can hardly stand. Robaxin does nothing for me either. It seems the only drug that works is Soma TID.

April 14, 2012 at 12:13 am
(60) Lorilyn says:

Flexeril has never done one thing for me. It never worked for whip-lashes, nor relaxing my (now don’t laugh) my butt muscles. Those muscles tighten up so tight on me, I can hardly stand. Robaxin does nothing for me either. It seems the only drug that works is Soma TID.

April 14, 2012 at 12:29 am
(61) Annabella says:

Hi , it could be a blessing that in Australia we don’t have the Cymbalta, Lyrica and all the other stuff that everyones is taking…I mean that my doctor will not prescribe those med to me 1, fir the side effect and 2. for the cost that its just prohibitive in Australia.
Because I have a very bad back, I do take Osteo Panadol 665 mg 6 x day, Tramadol 150mg slow release x 3 day and 50 mg Zydol immediate release 2xday, for the panic attack and relax I take 2 very low dosage (0.5)of Alprazolam per day. For the Fibro I went natural against the doctor recomendations: Vit D3 -1000Iu x 1 a day; Krill oil – 1000mg -2 x day; CoQ10- 200mg- 1x day; High Absorption Magnesium 100% Chelatd Magnesium 2t tablet each morning & night. and to boost my immune System I do take Colostrum Plus 2 capsules each morning & night and finally and most importand I take a 1 a day Mega B tablet. I purchase all my natural supplemnets from the USA manfacturer that its one of most reputable firm…I guess you have heard of Iherb…. Good luck every one..I do feel better .Annabella xx

April 14, 2012 at 12:57 am
(62) deb says:

I was actually prescribed 30-40mg of Flexeril at bedtime for my sleep problems. It does help me. My sleep problems had become so bad that I was watching the sun come up several times a week. My doctor thought it may give some therapeutic help for my muscles rather than just a sleeping pill.

As far as the constipation issues. I was already having issues with constipation. I take Amitiza for my chronic constipation.

This Fibromyalgia thing stinks and sometimes we have to pick the thing that helps the worst of our complaints. For me, the Flexeril at bedtime has been a great solution to the insomnia.

April 14, 2012 at 2:59 am
(63) Vicki says:

(69) Annabella says:Australia never has these drugs…!!!!!
Sorry Annabelle I have to disagree and I have no idea what doctor you are seeing but they would also know these drugs are available.

I still have not been diagnosed with Fibro even though I have suffered with it for most of my life, ever since my Horse Accident back in 1976. I have had chronic pain and RSL amongst a hell of a lot of other major issues ever since surgery also. I was lucky though to be able to work and then it wasn’t till another major accident in 2006 which has basically stopped me living a normal life, I too am on Panadol Osteo, 6 a day with a mild amount of relief, I have tried Cymbalta but the side effects with that along with Lyrica and another major one I cannot think of at the moment but we do have them all in Australia.
I am currently dropping my dosage of SR Oxycontin being down from 80mg twice a day and as much as it is painful have dropped down to 25mg twice a day. I take 50mg Tramadol when the pain gets too much, but again Tramadol is also an opiate so you are taking something more severe there than Cymbalta, which in its main use is for depression but also aids others with Chronic Pain.
I am also on Krill oil for my arthritis and it does work very well, but when you lay at night and not sleep or sleep for 40 mins and then awake for an hour, I have not had a decent nights sleep in over 15 years, it would be nice to think there would be something that helps other than staring at the ceiling.

April 14, 2012 at 3:00 am
(64) Vicki says:

I do however get all the information I can on a new medication as since I do drive , I am unable to do so for 2 weeks on taking a new medication and that is just how it goes. I am so fed up with my pain now that I was at the point of saying life has to be better than this, and yes it is but the medications is what is needed, I just wish that all the doctors would recognize all my pain for what it is and not for other issues. I know my body and I know the pain and if they just listened to me then they too would realize I do suffer either from Chronic Fatigue with a little of Fibro or it could be a combination of both.
I know that I am very sensitive to all new medications and give all at least a month but have been on all of them you mentioned we don’t have in Australia but we do. If I was able to work then maybe I too might also be able to afford chiropractic sessions and also some massages but since I am on limited funds it is very difficult even to buy some pain med’s some weeks.
Any new medication whilst it seems does not work for some but does work for others I would be willing myself to give it a chance, because having a good day a week is better than having 6 bad days a week.

April 14, 2012 at 8:18 am
(65) Teresa says:

Flexeril was the 2nd medicine that I was put on when I was diagnosed 11 years ago. I still take it and it helps with my always sore back, and with sleep. I won’t go without it. BTW, I take 20 mg each night, so I’m not sure that taking a low dose would help.

April 14, 2012 at 9:49 am
(66) fibrowendy says:

Yeah right….old drug and new formulation with lipids??? I don’t see this working out. I was taking 30mg of flexeril and it did nothing for me way back when.
I am not going to hold my breath waiting for this to work out and suck our pockets dry from co-pays! I am sticking with what works for me.

April 14, 2012 at 11:22 am
(67) dana tigani says:

It’s hard to see how this new drug will help. Flexeril didn’t help with sleep and made me feel hung over.

April 14, 2012 at 12:13 pm
(68) Shannon says:

Flexeril is closely chemically related to tricyclic antidepressants such as Elavil.

I’ve never been able to tolerate it because it dropped my already low blood pressure so that I risked doing a face plant every time I stood up. I also didn’t like its normal host of side effects such as significant dry mouth.

I suspect this is just another example of a drug company looking for a realtively cheap way to boost the profits on a previously generic drug. at best it would just treat symptoms and not get at a true cure.

April 14, 2012 at 12:33 pm
(69) BeckyG says:

I have taken Cyclopenzaprine for years, until recently when I changed my insurance company and they wanted prior authorization for it. My Dr. and I decided to try one on the list that did not require prior authorization. I took Cyclobenzaprine 10mg twice a day, I took the second dose @ bedtime. This worked fine for me most of the time. I could function with minimal pain. The new medication (Tizanidine 4mg) 2 is not enough and 3 knocks me out, all I want to do is sleep all day and don’t get the quality of sleep I got with Cyclobenzapine. We are in the process of getting a prior authorization for Cyclobenzaprine. it can’t be soon enough to suit me.

April 14, 2012 at 12:35 pm
(70) Robin says:

I’ve been taking Cyclobenzaprine 10 mg twice daily for back spasms–once in the morning and again in the afternoon. It helps and doesn’t make me tired. What does work at night though is Tizanidine. It does make me sleepy and helps with spasms throughout the night.

April 14, 2012 at 2:00 pm
(71) Carolyn says:

Flexeril never helped me even before my fibromyalgia. My doctor prescribed Baclofen and it works really good for me. I have terrible back spasms that can be difficult to manage if I let things go too far without doing anything. I take 10 mg in the morning, 10 mg in the late afternoon and then 20 mg at bedtime and it has worked so far. Flexeril would not do anything for me. I also take Tramadol as needed for breakthrough pain and I am already taking Cymbalta for depression. It just happened to be what worked to control my depression even before it was approved for pain management so I was taking it and didn’t even know it was helping with pain. I tried a tens unit, massage, heat, lidocaine, everything and finally my pain mgmt specialist put me on methadone. So now I take 30 mg a day divided into three doses. I like it more than the other opiates because I feel more in control of my senses and am able to function normally. Oxycontin and all the others cause terrible dreams and then I am also unable to function like a normal person. I am also taking Vitamin D. ubinquinol (form of CoQ10 enzyme) and I get B12 shots regularly. I try to take frequent rest periods, moderate exercise daily, and I am eating lots of healthy things. Another thing that I found that helps is D ribose and then Magnesium Malate.

April 14, 2012 at 2:22 pm
(72) BJ says:

I take Baclofen (a muscle relaxant) for my back problems, Fibromyalgia and Sjogren’s syndrome… Since I have been taking it at night along with my regular prescribed sleep medications, I have seen a significant change in my sleep.. For the better… But I agree with an earlier post… Flexeril is not nearly strong enough for most of us…

April 14, 2012 at 7:32 pm
(73) valerie says:

I use to take cyclo… it relaxed my muscles but didnt help me sleep. Doctor recently increased my amitrityline, but I had to cut back again due to druggy feeling the next morn. Gabapentin keeps the body radiation at bay. BIGGEST issue for me is FATIGUE. I’m so tired of being tired all the time.

April 14, 2012 at 8:19 pm
(74) Tina says:

I have been doing my own research and found a doctor who feels we should get off as much medication as we can and exercise, eat well, and take vitamins. I also had a sleep study which found I have sleep apnea so I use a CPAP machine. If we stop breathing, oxygen can not go to our brains or heart causing more brain fog, muscular pain, and fatigue. I went from no exercise to building myself up to walking 3 to 5 miles. The exercise causes our endorphins to kick in, our blood to flow, and get rid of lactic acid that is poison in our muscles. I thought I was going to die when I began walking but I have walked 3 5k races/walks. I never thought I could get this far. I also was in physical therapy learning special exercises to stretch my muscles and strengthen my core muscles. I have felt better going off many of my medications. Taking the meds cause so many side effects that mimic fibromyalgia symptoms. I could not tell if it was the side effects of medication or my fibro which was causing the pain. Watch out for cholesterol lowering meds for some cause muscular pain. I know my treatment may not work for everyone, but if we can get away from chemicals it will really help our bodies and minds. We are being bombarded by chemicals in our food, all kinds of products, and in our environment. I wish you all well in your journey to find relief from your chronic pain and fatigue

April 16, 2012 at 1:03 am
(75) Leslie says:

As far as constipation, I wouldn’t mind taking something that causes constipation, since I have IBS-D. But I worry about it drying me out. Are there any muscle relaxers that don’t dry one out. A few years ago, I was on a muscle relaxer for my gut that was really drying. It helped the rest of my muscles relax, too. But I was so dehydrated that I wound up with an arterial blood clot in my kidnay and lost a chunk of it. I am now terrified of drying medications, needless to say.

April 16, 2012 at 3:53 pm
(76) Gramma Anna says:

Wow ! ~ all these comments prove that different treatments affect different people, well – differently! Interesting read. Me? FM / Myofacial Pain Syndrome / severe osteoarthritis for @ least a coupla decades.
Flexaril helps me sleep . . and sleep & sleep & sleep! For 18 hrs or so. Same with Elavil; Melatonin gives me night terrors; Gabapentin works but is costly. Too bad ‘cuz it’s good for dogs with arthritis, too!
I use Tyl #3 & Morphine sulfate for pain management – will try some of the ideas for cramps – which I get in my feet & toes, shins, thighs, hands & fingers,etc. No “charlie horse” cramps, tho? Weird, huh?
Main problem (still) is convincing people I am not lazy or crazy – just hazy! And that my late nites -til 2 or 3am- are not by choice. Sheesh – this is always the most challenging hurdle.
Keep up the comments, love to read ‘em!

April 16, 2012 at 6:24 pm
(77) Annie says:

Terrible drug. It destroys your stomach. Won’t touch it!

April 16, 2012 at 9:04 pm
(78) Beverly Letsche says:

I took Flexril for years and it was generally effective to relax muscle spasms when taken on a as needed basis. I tried taking it daily to improve sleep but never felt it was effective. Eventually it seemed to lose effectiveness and I moved on to different muscle relaxers. I am currently taking Baclofen.
As for the person who has IBS-D, have you tried taking probiotics? It has made a huge difference with my IBS.

April 17, 2012 at 1:54 pm
(79) georgia says:

To Gramma Anna,
I, too, suffer from Fibro, Myofascial Pain, & severe Osteoarthritis. I’m sorry to hear that your suffering has been for a coupla decades & because mine has been going on for “only” five years now, wondered if the pain can get worse? Supposedly Fibro isn’t progressive however Osteoarthritis certainly is & I simply can’t imagine things hurting any worse than they do now. I truly fear being crippled by all of this. In my efforts to remain mobile, I eat healthy, stay slim & exercise in a heated therapeutic pool every day.

I’m 56 years old & I fear the future. I would truly appreciate your comments (or ones from others on this subject).

Thank you!

April 19, 2012 at 7:26 pm
(80) Annette says:

I can not take flexiril asair gives me restless sleep, but, I do take the muscle relaxant, Skelaxin every night at bedtime & it helps greatly! I could be a poster child for Lyrica, it has made a HUGE difference for me!

April 20, 2012 at 8:30 pm
(81) Alanna Sage says:

I take the generic for Flexeril along with Tramadol and Effexor to help me with the pain & discomfort of Fibromyalgia. It does help take the edge off but the stiffness never goes away. I was given the Flexeril mostly for the muscle spasms and charlie horses I get in my feet, legs, back, etc. I forget sometimes to take it because I’m feeling good and pay for it later big time! It is very helpful at bedtime as I’m able to get much need rest.

April 24, 2012 at 4:02 am
(82) Margaret says:

I was just prescribed flexeril ER (generic for Amrix) last month and it was wonderful. Taking it combined with my sleep medicine finally worked and i was out of insomnia hell for a month (before this not even 3 Ambiens would make me even drowsy). Not only did i sleep but my spasms felt better during the day, probably partly from the extended release still working, but also partly because i could finally sleep. So i go to refill my prescription last week and what do i find? NOBODY has it. Nobody can GET it. It is on back order at every pharmacy i called and they do not even know when to expect it. This same kind of crap was pulled with my Adderall several months ago. This is really bumming me out because the namebrand Amrix is 100 bucks for 30 tabs and I just can’t do that. I sure as heck hope someone is working on another generic form and soon.

April 26, 2012 at 6:24 am
(83) Overlapping of Fibromyalgia Syndrome Symptoms says:


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April 28, 2012 at 5:04 pm
(84) Patti says:

Cyclobenzaprine was one of the first meds ever prescribed for me once I started having symptoms 23 yrs ago, and I still take it. I started at 10 mg and I still use 10 mg, once a day before bed. Very occasionally I get severe tension headaches, and I will increase the dose for that night to 12.5 or 15 mg. I can’t imagine ever being without it.

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September 10, 2012 at 9:13 am
(86) Christy says:

Is this for real a Lipid? I hate Flexaril gives me hallucinations and hung over effect for days. I am on new medications every 30 days b/c I have so many issues with medication for this condition. (The current 30 days) since 9/7/12 been on: Limbrel 500 2x a day..does nothing, 2. Baclofen 3x a day..muscle spasm help/drowsiness not working..Metanx..does nothing and 4. Perocet (off brand) 5/325 1x a day if I am lucky it will take edge off pain for 2-4hrs. Diagnosed since 2005, I have been on everything available. My stomach is so sensitive I can’t take things like Celebrex. Lyrica make me nauseted for about 12hrs a day, even when taken with food. Savella, Gabapentin..do not work or Gabapentin may work for 1-30 days and then stop working. I become immune to every pill for fibromyalgia otherwise. I have osteoarthritis in the spine, carpel tunnel issues..not right now thank god, back spasms, deg disk disease, bulging disks, I walk with a limp randomly b/c feels like hip or ankle or knee or going out. I have uncontrolled sleep apnea (been thru 3 masks and still throw if off at night) I simply do not know how some of you noting all the things you done can afford this. I am waiting on disability to be approved which is a nightmare to go thru even after getting a lawyer. I have to decide between I wonder if this med will work and buying it and getting food for my family. I need to be in these studies. I need something for depression (this does not make me go to the bathroom several times a day), something for pain (narcotic), something for sleep (? Zanaflex..gives hallucinations but can’t take traditional sleep meds b/c of sleep apnea), something for energy. Once someone has this someone email me..HAHA.

November 22, 2012 at 12:21 am
(87) Angela says:

Hi there everybody, I have gabapentin 600mg three times a day. I have a sleep med zoplicone 7mg at bedtime, amitriptyline 10mg at bed time.
Than I take a pill to control my out of control bladder. Then I also top up with over the counter pain killers. Over here in the UK my doctor prescribe me these meds but refuse point blank in changing this medication. When they don’t work, I take a drug holiday, then go back on them. It’s a struggle, I have constant pain, it is relentless. I have to use wheel chair when I go out. Forget sleep, it just never happens. My doctor is like, drink a small alcoholic drink before bedtime. It’s a joke.
As far as a new drug go’s it’s bull, some body needs to fine a cure.
And find out why this fibromyalgia happens. There also need to be educational lessons for all doctor on this subjective matter. Most doctors are ignorant when it comes to people with fibromyalgia. These drug companies are out to make millions on the back of us suffering with this condition. Why do they not test it on people with FMS. Poppy cock. That’s what I think.

January 18, 2013 at 1:44 am
(88) anglia says:

i have been taking it for years and it does not work.

March 1, 2013 at 4:16 pm
(89) Pina says:

that is a joke cyclobenzaprine we want a pill to get us out of chronic pain day in day out what about searching savella in the usa just gety all of us out of chronic pain please we all suffer enough thank-you
with fibromyalgia

May 3, 2013 at 10:52 am
(90) Beth B. says:

Took Flexaril but it did nothing. Taking Mirtazipine, Xanax, Baclofen and Tramadol before bed and that combo works like a charm and am getting 8 hours of sleep – interrupted by pain when I have to move but I eventually get back to sleep. Body won’t go to sleep though until 2-3am. The meds wear off after 4 hours so by the time I awake I’m in such horrible pain. Taking a combo of vitamins and minerals I researched in my medical classes for Fibro, Hashimoto’s, Sjogren’s. Nothing works for the flare-ups though – they still make me feel like I’m going to die. Lyrica, Cymbalta, Gabapentin, Savella all made me feel much worse…they need to come up with something better than lipids & Flexaril! Seriously??ahahahahaha

December 4, 2013 at 1:32 am
(91) Rob says:

Come on. I’m sick of the “fear” and stigma behind using what works for PAIN.. Opioids/Opiates
If someone has a chronic condition that has no end in sight.. the problem of dependency and/or addiction is a moot one. It comes down to quality of life, improved function at home, work, and in recreation — for a balanced lifestyle. In many people it takes Hydrocodone, or time released preparations of Oxycodone (or other such medications).. perhaps some get by with Tramadol and Hydrocodone to take as needed (which is more than reasonable).. but the point is a new drug like this is not a new drug at all.
It is Flexeril, and Fatty acids. If someone has chronic pain for literally the rest of their life (the least physicians can do is prescribe adequate amounts of these “evil” painkillers.
Quality of life should ALWAYS trump worry of addiction and dependence.
It further irritates me with some doctors who won’t prescribe any medications that work if the patient can’t produce some undeniably messed up scan.. ie: A major disc disorder in the spine via CAT/MRI… There are millions of people in tremendous pain 24 hours a day, 365 days a year who are considering if life is worth living who CAN be tremendously helped if doctors would only treat them.
Just because you can’t see it on a scan .. doesn’t make it any less painful and any less REAL.
Sorry for the rant, but it is simply inhumane to not adequately treat chronic debilitating pain because of stigma.
Further our government needs to back off of doctors prescribing habits,.. some doctors really want to help but need to substantiate their prescribing habits and those without some physical evidence are difficult to substantiate other than the word of the patient and the notation of the doctor.
In my opinion, if a patient is willing to regularly see the prescribing doctor, then any level of daily medication is up to the doctors discretion — not our politicians.

December 11, 2013 at 1:13 am
(92) Mareeda says:

NO after dislocating my right shoulder 6 mos. ago this nightmare has aggressively stole my life. The flexeril is a joke. 36 yrs of endometreosis,ddd,osteartritis,panic anxiety,depression,insomnia,L4.L5,S1 herniated collapsing disk I have seriquil,remoron,zanax for sleep and I keep taking as many as I have to in order to sleep, The baclofen takes the edge off spazems. I agree with Rob the about stigma and the damn addicts ruin it for getting adequate pain treatment as the ms,contin only works when the headaches,nausea,pulling out of the muscles,cystitis,is already tolorable lol. Only good thing is the polyethylene glycol helps with constipaion. My PAIN is so severe I’m a prisoner in my own bed ridden body even a store trip takes days of painful somewhat recovery. My life is over no friends or playing with grandkids or fun(whatever that is). I have added osteo-biflex.vitemanD3,multi-vitemans,fish oil, etc,,,,,,,,,,,, I can’t even go get my med’s so its a battle not to just give up~glad I found this finally others that can relate! So basically fybro is a death sentance because lyrica,effxor,cymbalta just intensified my symtems

January 13, 2014 at 10:44 am
(93) BeejayNZ says:

I am 44 years old and have been diagnos with Fibro/Musclular Skeleton/Arthritis. I probably get 2 nights sleep a week. Amytriptaline does nothing. 3 x 7.5mg may work if im not stressed to much before going to bed. 3 x tramadol 4 times a day, Gabapentine 600mg daily, dycloflynac x 2 tablets a day. I feel like a lab rat being used as a experiment subject. Does it work? sometimes. I think the cure is education and knowledge of fibro, understanding that stress causes alot of the symptoms and changing your lifestyle to accomadate the pain.

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