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Adrienne Dellwo

Savella for Fibromyalgia: Have You Tried It?

By June 12, 2009

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The newest FDA-approved fibromyalgia drug, Savella (milnacipran), has been on the market for more than a month now, and I'm anxious to hear how it's working for people. Have you tried it? How is it working? Take the poll and leave a comment below to let us know!

If you're not familiar with Savella, it's an SNRI like Cymbalta (duloxetine), except that it boosts norepinephrine more than serotonin. It's been approved in several countries for depression for several years now, and it appears to have fewer side effects than most drugs in its class.

Comments
June 12, 2009 at 12:05 pm
(1) Ronaldo says:

Chronic pain is very severe and this affects people’s life, long known to people who suffered from a strange disease, were strong back pains, which were intense and not let them work, as was what they said were the doctor and he prescribed oxycodone for pain, but knew it was a very powerful medicine, and moreover, anxiolytics, and worry that they were doing things that previously did not like eating too much, smoking, etc, and read in findrxonline that this drug is well and that we must be very careful with their use, and everything must be under medical prescription.

June 12, 2009 at 1:10 pm
(2) Nancy A. says:

I’m still on Lyrica and I also take some Tylenol every day for my pain. I just finished weaning myself off Cymbalta which has too many side effects for me. So, I’m not really anxious to try another antidepressant (I’ve tried several) right now.

I’m more interested in other types of drugs being approved for fibromyalgia: Ampligen and Xyrem for instance.

February 11, 2011 at 4:05 pm
(3) Linda says:

I just started on Savella and it seems like a wonder drug so far. I haven’t felt this good in years. I had been on 150 mg. Elavil and 150 mg of Lyrica. The Lyrica made me brain dead most of the time and the Elavil made me brain dead in the morning, plus I still had a lot of pain. I have begun a log to keep track of my symptoms. I tried Cymbalta last year and it made me very sick, sweating, nausea and couldn’t sleep.
So far, this looks good!

March 17, 2011 at 10:51 pm
(4) janice says:

Linda, Just wondering how u r doing on the savella. I just starting taking it and it seems I am feeling sick and real tired and not doing much for pain. I don’t won’t to give up on it to soon becuase it could b the one thing that will help. I just know that after 3 wks I feel so tired and sick.
Janis

August 15, 2011 at 2:29 am
(5) Aj says:

I suggest Savella for fibro, with a strong recommendation to titrate up very very slowly until the top dose, and possibly before top dose if you feel well before then. I took triple the time recommended to titrate up, as my doc had discovered that none of her patients could tolerate the side effects when following the timing directions on the box. As my body adjusted, Savella helped with pain and with strength!
I believe Xyrem is plain scary. After getting a script for Xyrem, I watched their video and read about it. Even though I had paid out of pocket, I chose not to take it…just seemed too risky…and my quality of life was horrendous at the time. The risks were too high for me. Savella works for me.

June 12, 2009 at 3:19 pm
(6) Bill Cohen says:

Neither Ampligen nor Xyrem are currently approved for fibromyalgia.

June 12, 2009 at 3:20 pm
(7) bob says:

yes, started in march 09. it helps, still get a lot of pain when i over do it, but my daily quality of life is improved. side effects, sweating, and as they call it, difficulty passing urine. (so far, trade off for a better less bad day is fair). some days the side effects are worse than others, but mood, and daily life are improved on savella. (had to stay up at 100mg twice daily to retain the benifits). good luck all… hang in there. Bob.

June 13, 2009 at 2:08 am
(8) Dint says:

I really don’t see the point of these drugs. My muscles are completely stretched taught. If I stretch, my body sounds like a tree splitting apart. The pain comes from my muscles and fascia. It comes from my hip flexors. All of my trigger points are large knots of pain. How is an anti-depressant supposed to make that go away? I have tried a few of these “treatments” with absolutely no change in my pain threshold but an entire host of ill-effects such as personality changes, extreme weight gain, suicidal thoughts, the works.

What does help are narcotics. Even the smallest amount of tramadol will at least reduce the pain by a fraction. These anti-depressants don’t even dent that pain no matter how much I take. If I take stronger narcotics, the pain goes away more.

My pain is severe and I have been approved to take kadian. I tried it for a month. It did the most help. But I don’t feel comfortable taking it. I currently take tramadol and soma. This leaves me unable to do as much and keeps me in pain. But the pain is not so bad that I feel trapped by it.

I know this is not a story about sevella. But I strongly feel that these drugs are doing us a great deal of harm. I have known more than a few people who suffered hell trying to stop medications like Cymbalta.

I just don’t see the point in these drugs when we already have pain medication that works for most of us. The risks of these drugs seem enormous compared to safe use of opiates.

April 23, 2011 at 12:12 pm
(9) Linda says:

I have to somewhat agree with you. I have the same type of pain you do. Tight muscles and sascia and let’s not even talk about my hip flexors. Pinched nerves, you name it. Been going for physically thereapy for 9 months. The massage the trigger points, stretch me, etc. I can’t say it’s helped all that much. After 9 months, I was hoping for more. I’ve been on Savela for about 10 months. I had NO side effects. None at all. In the beginning I thought it was helping, but now, it feels like I’m taking a placebo. I was wondering if you just build up an immunity to it. In any event, nothing has seemed to work and none of my doctors (and I have many) will put me on any type of pain killers. Muscle Relaxers and Anti-inflamatory drugs – that’s it. Wish there was a better way – just can’t live like this anymore.

June 13, 2009 at 10:55 am
(10) Clamshack says:

Started Savella for fibro but also have chronic fatigue. Sleeping more than 10 hours daytime and all night. Not sure why??

June 13, 2009 at 7:03 pm
(11) fogmom says:

I’ve been taking Savella for 3 weeks now. The knots in my muscles have relaxed and are almost gone. It does nothing as far as an antidepressant, but it does help the pain as long as I don’t over do it. I’ve been able to cut my vicodin use in half. For me it has helped so far.

June 14, 2009 at 9:59 am
(12) judy says:

A,
I am looking at Savella and waiting to hear more. Did Cymbalta for 2 years, bad side effects. No problem stopping the drug.
Dr. backed me off in a 2 week period. Seeing a TCM/Western Chineese MD/professor/acupucturist. She put me on Mood Food [health food store] high in 5HTP.
I am not depressed acually best I have been in years. She also put me on Vine Essence[a Chineese herb] along with weekly acu. and did a hair analisis. I am now on a regimine of supplements. My skin has improved , dark circles under eyes and wrinles are disapearing.
I am cutting back on Oxycodone now as so much is not needed.
Most of all,I want to say, THANK YOU for your hard work and dedication to this site.
You to have FMS and a small child.
We all should step back and give you a round of applause.
Judy

May 7, 2011 at 11:29 am
(13) lisa says:

I know it has been 2 years, but……..have you had long-term success with the Mood Food, and the Vine Esssence? And please, what additional alternative treatments taken for fibro and chronic pain have worked for you? Thank you so much for sharing! — lisa

June 14, 2009 at 12:24 pm
(14) LindaS says:

I was on Savella a couple of years ago for a clinical trial study. It didn’t do anything for me. I am now trying it again – but so far not feeling any different after one week. I tried Cymbalta a couple years ago and it worked great for one month – then pain started to come right back.

April 29, 2011 at 12:48 pm
(15) Robin S says:

I am on Savella and my Dr gave me flexeril to take at 7pm it helps me sleep a restful sleep. I feel alot better. I think alot of fibro is that we don’t get in a deep sleep therefore it feels like we stayed up all night even though we think we have slept its not in that rem you have to be in not to be tired.

June 19, 2009 at 3:25 am
(16) Patricia H says:

My doctor gave me a trial pack and after two days I noticed I had a tremendous amount of energy and my migraines are gone. I took Vioxx for years due to arthritis and fibromyalgia, until they took it off the market. Savella is the next best thing to it. As far as other meds, I tried Cymbalta and had allergic reactions since I’m allergic to ragweed. Lyrica caused severe migraines,blurred vision, dry mouth/throat, night leg cramps, brain fog and made driving a car practically impossible. After taking Savella for a few weeks and adjusting the dosage, I am nearly pain free.

June 19, 2009 at 4:02 pm
(17) Shelly says:

Am on my second trial pack of Savela, first time I thought I had a virus, nausea, tired, sweating at night and day. On it again and same thing, so I know it wasn’t a virus the first time. Am frustrated because Lyrica worked for me, but insurance company won’t approve.
Red tape…be gone! :)

June 19, 2009 at 6:34 pm
(18) Mary says:

I have been on Savella for 3 weeks now and am feeling some relief. My doctor wanted me to come off of Lyrica all together to see if the Savella would “take over” for the Lyrica, but that didn’t work. I have managed to cut my daily dosage of Lyrica in half which cuts the side effects as well! As far as side effects of Savella, I’ve only noticed that I was a bit moody the first week of the full dose, but this last week has been so much better. I’m really hoping that Dr & I are close to a good drug combo.

It sounds like this drug is helping alot of people!!!! Don’t be afraid to take it just because it works like an anti-depressant.

June 19, 2009 at 7:38 pm
(19) lea says:

I have been on Savella ever since it has been approved for use. I don’t have the pain like i once did. I do notice night sweats and daily sweats, but will continue using it since the pain is so much better. I am so happy to finally find something that helps. TY for all the work you do for fibro.

June 19, 2009 at 9:13 pm
(20) Carrol says:

I have been considering asking about this but I had such a bad time w/cymbalta & didn’t realize that the side effects were so bad until I realized one day that I had lost my desire for life & just about anything else. I didn’t have any trouble stopping it but now am a little “scared” of starting a new drug since it took 2 yrs on cymbalta for me to realize how bad I had gotten while I was still in alot of pain. These good comments make it sound like it is helping alot of people tho so it is something I may talk to my doc about next time I go in & see what she thinks.

June 22, 2009 at 12:21 am
(21) Chere says:

I have just been on this for 3 days , this is after having a 5th back surgery, in 14 yrs. Have been diagnoised with FMS since 1996, Lyrica was not good, but after 3 days the hypersensitivity I had in my back is GONE. I can where pants again. Move more freely then I had been. This is a God sent medication.
THANKS for continuing to find medication to help those of us who suffer in constant pain.
Cher’e

June 22, 2009 at 4:47 am
(22) susiedal says:

From some comments, it seems that Cymbalta has some undesireable side effects. What are they? Is sweating one of them? I take Effexor now and dread summer time because of the sweating! Does the new drug that raises norepinephrine levels also cause sweating and sleeplessness?

June 22, 2009 at 2:07 pm
(23) Angela says:

I have been on Savella almost three weeks now and noticed a difference in my pain & muscles. More of a difference than anything else I have ever tried. I tried Cymbalta for about six months or so and did not notice any difference the side effects were terrible and coming off of it were terrible. I tried Lyrica for about two months it did nothing for me plus my insurance would not pay. My doctor over the past four years has tried so many different meds on me and nothing really works or there are bad side effects. Everybody is differnt. So far Savella has been the best but different times of the year I am worse so time will tell and so far no side effects except a slight more tired, and it does not act like an antidepressant which I don’t need anyway just daily muscle and pain relief. I am crossing my fingers because all that I have had is bad luck with meds. Good Luck to everyone else!!!!

June 23, 2009 at 10:59 am
(24) Sylvia says:

I have been using Savella for 3 weeks now, with little or no improvement in my FMS/CFS symptoms…so disappointing! Cymbalta and Lyrica were not effective for me either. My Dr. finally gave me a prescription for Vicodin to help with pain. That has not helped either. (Does not even take the edge off) I’m back taking more OTC Excedrin, the only thing that helps me, but is very bad for my stomach (acid reflux)although the Prilosec helps w/that. I survive on Mirapex for RLS, Prilosec, and Excedrin. I am so disappointed that the Savella hasn’t helped. Will stay on it a little longer to see if it changes.

June 23, 2009 at 4:40 pm
(25) chronicfatigue says:

Susiedal,

Here’s information on Savella & Cymbalta that includes lists of side effects: Savella, Cymbalta.

June 25, 2009 at 2:43 pm
(26) Sue B says:

I have been on Savella for about 10 days. I am ramping up the dosage slower than the trial pack says. My dr agrees I should because I have had a lot of trouble with disabling sleepiness when trying other meds. I’m up to 25mg each morning now. I feel more energetic and less tired than I have in years. Pain has never been my big issue. I have RA and scoliosis as well as FM, so I am on longterm maintenance NSAIDs. Pain in trigger points has not been helped by the other pain meds. I just live with it, although massage helps. Savella seems to be starting to diminish trigger point pain, but I can’t be sure till I get up to higher dosage or longer use duration. Side effects have been limited to mild queasiness and transient headaches. Queasiness is helped by not having an empty stomach and by drinking salty things like V8. The improvement in my energy level is enough that I am willing to deal with the nausea. If I am this improved on 1/4 of the normal dose, I’m not sure I even need to go up to the full dose.

June 26, 2009 at 12:03 am
(27) DefiantOne says:

I was on the ramped Savella for 7 days. My pain diminished intensly. I was tired, but with Fibro, I’m always tired. I had, and still have some weird skin-creepy feelings. But the reason I had to stop taking it is I passed out twice. My blood sugar and blood pressure dropped. By the time I made it to the Dr’s my blood sugar was 53 and blood pressure was 78/50. Today blood sugar is up to 84 and bp is 90/60. These drops caused my heart to go bananas too. The Dr isn’t 100% sure it’s the Savella and I hope to try it again in the future because I had virtually no pain by day 4.
Anyone else have this problem?

June 26, 2009 at 12:03 pm
(28) Amy says:

I am trying Savella now.
It helps with pain but is making me very tired. Sleepy, don’t want to move kind of tired.

Lyrica with Celebrex brings my pain from a 9 to a 2. Cymbalta brought it to a 0 to 1, but made me paranoid and my anxiety went through the roof.

I tried narcotics with nurontin and that only brought my pain to a 3.

The Co-ox 2 inhibitors like vioxx and Celebrex, just plain work. Lyrica helps with the muscles. Add the SNRI’s if you can stand them and you’re home free.

June 26, 2009 at 4:53 pm
(29) Shayna says:

I have transitioned from 120 of cymbalta to 100 of Savella over the past 2 weeks. It has helped very much for the pain but I am also experiencing profuse sweating night and day. It has helped my energy level almost too much; if anything I’m feeling manic and my usually low normal blood pressure has gone up. One good thing is that it has totally taken away my food cravings!! I have to remember to eat and lost about 10 pounds since I started. Problem— Medicare RX will not lower it from Tier 3 to Tier 2. I am appealing.

June 27, 2009 at 11:00 am
(30) alycep says:

I have been on Savella for fibro for 2 1/2 weeks-just got to the full dose. I agree the muscle pain is less and although I had stomach upset the first week that is gone now. At this point my main negative side effect is severe sweating-I am soaking wet all the time. I have tried all the other drugs and had much worse side effects and little to no relief so at this point this one is better. I also have psoriatic and osteo arthritis and some other tings and I take large doses of prescription ibubrofen.

June 28, 2009 at 10:26 am
(31) John M says:

I have been taking Savella for almost two weeks now. Since I have been on it, I have been experiencing more generalized anxiety and heart palpitations. My blood pressure has also been up and down. Sometimes it has been 125/91 and other times at 100/69. My pulse is also up and down. It has been up to as high as 110 while at rest. I have had anxiety and depression for several years now, and it appears that Savella is making the anxiety worse instead of better–which is what my doctor had hoped. I also seem to have problems urinating sometimes, which Savella can cause. I am not sure whether I should start dropping the dose and prepare to get off the medication or not. I have tried everything and nothing works. All the antidepressants just make me worse.

The one antidepressant that did seem to work somewhat was Lexapro, but I had to stop it due to it causing my prostate to tightening up where I couldn’t use the bathroom. The bad thing is that I am only 26, so I shouldn’t even have prostate problems.

I may give the Savella a few more days, but if it continues to cause me problems I will get off it. I have just about given up hope for ever finding a drug to help with my fibromyalgia pain. My doctor never offers to put me on more powerful pain meds. I know he doesn’t want me to get addicted to them, but sometimes you just have to take what you can take in order to be able to function. I haven’t been able to have a real life for the last 7 years. I stay mostly at home due to my fibromyalgia pain and depression/anxiety. It has become a hassle just to leave the house.

I would also be interested to know if anyone on here experiences the veins and arteries dilating or popping up under their skin with fibromyalgia. I seem to experience this whenever I get hot or really stressed. It feels like they are going to pop out of my skin. It is very painful. My doctor can’t give me a good explanation as to why it happens. I just hope that one day there will be something that I can find to end this horrible fatigue and pain! Good luck to everyone on finding a treatment.

June 28, 2009 at 8:54 pm
(32) Darin says:

I have been on it for 3 weeks and all i can say is so far so Great lol most of not all of my symptoms of firbo is either gone or way much better…time will tell.

June 29, 2009 at 4:08 pm
(33) Vandamir says:

I was on Flexeril for Fibromyalgia for more than 15 years and it worked well for me up until last September. I was diagnosed with Sleep Apnea at that time and it created a pain cycle I haven’t been able to get out of. Also the Flexeril was damaging my liver. I’ve been off Flexeril since June 11th and yesterday was the first day where I didn’t experience any withdrawal symptoms from it even though I gradually decreased the dosage over a four month period. Flexeril is chemically related to tricyclic antidepressants so works on the brain in similar ways as Cymbalta and Savella.

Since September I’ve tried a variety of medications including Lyric, Gabapentin, Tramadol and even Viagra (which stopped the pain and fatigue immediately but after a few months the side-effects – flushed face and blurry vision – became too dangerous for me to continue on it). I was on Savella for under a week and experienced the nausea, sweating, and extreme tiredness others mentioned. I stopped taking it because it also caused a rash and my skin felt like it was burning. My doctor is going to put me on Effexor next and we’ll see how that helps. Currently also taking Klonopin for sleep and anxiety. Heard from another doctor who has FM herself that Low Dose Naltrexone (1-10mg) has really helped her so I’ll discuss that with my doctor this week as well.

I also see an acupuncturist who is a Chinese herbalist and he’s put me on a couple of supplements that have helped. I’m taking Cordyceps (a mushroom capsule) twice a day to help with fatigue and a natural relaxant with Valerian Root and Passionflower called Formula 303 to help me sleep. Found it’s also important to take Magnesium supplements because the pain is worse if I forget to take at least 500mg a day. Through the help of my acupuncturist and Chinese herbs the damage to my liver has been reversed and I’m even experiencing less IBS symptoms.

I’m currently on a leave of absence from my job because the pain was so intense and the side-effects from the meds were making it impossible for me to work. This is the worst flare-up I’ve had since I was diagnosed 16 years ago. I know there’s hope out there, though, it’s just finding the right combination of medications that works for me. Good luck and blessings to everyone else who is suffering!

July 2, 2009 at 11:20 pm
(34) Kim says:

John M…you stated, “I would also be interested to know if anyone on here experiences the veins and arteries dilating or popping up under their skin with fibromyalgia. I seem to experience this whenever I get hot or really stressed. It feels like they are going to pop out of my skin. It is very painful.” I too have the same symptom and pain, specially on the top of my hands. You are not alone. My doc who specializes said it is a symptom of FM. Best in health to you.

July 3, 2009 at 11:01 am
(35) Cathy says:

I was on Savella for 5 days. Very scary stuff! Heart palpitations, blurred vision, sweating, mania, out-of-body experience. And, that was on the starting dose of 12.5 twice a day. I have high blood pressure (being treated), and I am bipolar (being treated). But this stuff was the worst of all meds for me. I have tried Lyrica, and it didn’t do much. I will stick with Tramadol. I take lowest dose possible and
it seems to help some, without all those side effects.

July 7, 2009 at 5:34 pm
(36) homesheba says:

it made my hear beat so hard and terrible sweats. was on it as long as i could stand- 2 weeks. took myself off before i had heart attack.

July 8, 2009 at 3:14 pm
(37) Leah says:

I was in a clinical study for Xyrem and it felt like it completely cured my Fibromyalgia. I have tried quite a few other things since that time but nothing is working. I had the WORST time on Lyrica. The side effects were so bad it actually made having FMS not seem so bad. Needless to say, I am trying Savella now and hoping that it works for me because I have no idea how long it will take the FDA to approve Xyrem for the treatment of FMS. I hope that day comes soon though because at least I know that Xyrem DOES work for me.

July 13, 2009 at 5:57 pm
(38) Neil says:

I have the feeling that we all have different disorders but have been given this crap diagnosis, we all have these weird symptoms and some people have really specific and distinct ones that others don’t, we all have different levels of pain and different types of pain, just different everything. This diagnosis is crap, I hate my life

March 20, 2011 at 4:39 am
(39) Meredith says:

Part 1 : I just ‘discovered’ this site, I see that most of the posts are from Two years ago. Neil, don’t give up and in these two years, I hope that you have found the right thing ‘for you’. I had not heard of Savella until this past week. Fortunately, I had my pain dr. app’t 4 days ago.

March 20, 2011 at 4:42 am
(40) Meredith says:

part 2:
I understand wanting to give up. Yet, everyone who posts, MUST have a Glimmer of Hope because, you wouldn’t take your time. I had Nothing left to Lose..Nothing. I am still dealing with Floods of Emotion of ‘being well’ and ‘feeling normal’. NO Complaints about that, my pleasure. I liken it to an innocent convicted prisoner that was just released after 20 years of hell. Some prisoners, go back to prison because, it was a safe place for them and have no clue how to cope in the real world.

March 20, 2011 at 4:44 am
(41) Meredith says:

Part 3:

Well, I am NOT going back as long as this medication works and I will learn to cope in a life that is like I have NEVER experienced Ever to this degree.
If I had side effects of puking 10 times a day, headaches for an hour or so a day and so on, I’d deal. I have all 5 senses back and had no clue that I had lost them to a Great degree ! I am touching all kinds of materials against the skin that felt pain from even my hair touching my face.

March 20, 2011 at 4:46 am
(42) Meredith says:

Part 4: last one.

May you and all of those that suffer the living hell, that I know so well, get relief with Something – keep trying. We’re all unique and so are the medications. I had already planned, before I felt well (it is hard to even believe that I can say that)..anyway, to start a Non Profit Organization that is for Chronic Pain Research, Fibromyalgia Primary. This will be a million times easier without pain and maybe, just maybe, there will be something discovered that covers ALL sufferers. Hope Springs Eternal. Blessings.

July 15, 2009 at 3:49 pm
(43) CeCe says:

I was on Cymbalta, and truly hit rock bottom. I was on Effexor for a while, Lyrica, and some other meds. I have been on Savella for a month, and so far, it has been better than everything else. I have some bad headaches from time to time, but that can be due to anything.

I am honestly sick of all meds, but I am thankful that they are out there. One day, none of this will be necessary. Until then, let’s hang on! :-)

October 18, 2011 at 6:51 pm
(44) Linda Waters says:

I read your blog about Savella. I am just starting on it for my fibromyalgia and lupus. I feel as you do-sick of taking all these medicines, but thankful. What did you mean by “One day, none of this will be necessary”
Please reply AS SOON AS POSSIBLE

July 16, 2009 at 8:49 am
(45) Molly says:

Neil, it will be alright! I know it seems hopeless, I look at this list and I am grateful that I don’t have some of the same symptoms others are having. I have been on Lyrica for three months now and I didn’t know how bad I was until I found some relief. I wish I could be a lot better but truth be told I can still count blessings. Look for a support group I hope you find some help.

July 17, 2009 at 3:49 pm
(46) Nanette says:

I was diagnosed with fibromyalgia over 10 years ago. I had gotten to the point of having to take a narcotic (darvocet, at least twice a day), muscle relaxant (also at least twice a day), cymbalta, lyrica, and advil as an extra on those especially bad days. I also have had to walk with a cane for the past eight years. I began Savella about five weeks ago because the medicine regime was beginning to stop working – it was either up dosages or try something new. With Savella I have been able to eliminate ALL other meds – I don’t need to use my cane all the time!

July 17, 2009 at 4:41 pm
(47) K says:

Hope others have better luck. I had severe nausea, headaches, dizziness, and vomited until I discontinued only after a couple of days. Severe abdominal cramping and diarrhea as well.

July 20, 2009 at 6:25 pm
(48) Danielle says:

I was diagnosed with Fibro 7 yrs ago – have tried it all – flexeril, ibuprofen, robaxin, baclofen, valium, cymbalta, lyrica, nuerontin, vicodin, chiropractic, herbs and more.

But several months ago after a dislocated hip and rolled ankle (seperate incidents and only in my 30′s) the Dr tested my Vitamin D level and was shocked!!! It was only 4 and the lowest acceptable level should be 50-100. So started prescription strength Vitamin D2 and I feel 80% better…. guess what the symptoms of Vitamin D deficiency are??? Muscle pain, tender spots, fatique..etc… does this sound familiar! So I suggest anyone with Fibro get tested.

I take 50,000 IU twice a week (Dr says some Docs say once a week but twice seems to work better) It is a fat soluable vitamin so you can overdose – so they check my levels every three months. My current level is only up to 20 and I feel much better – hope when I get to 80 (Docs goal) I will feel like a normal person.

July 22, 2009 at 7:54 am
(49) Cathy says:

My dr.ask me to research Savella so we can talk about this next visit. I have been taking
lyrica since they approved for fms. But I think it has affected my vision alot. The only thing I have seen that lyrica works for is the burnning stabbing pain in my shoulders.
Was wondering if the savella helps with this type of pain. I think I might stop the lyrica or have dr cut the dose from 200mg down to 100mg a day. If anyone has this burning stabbing pain let me know what you do
thanks

August 1, 2009 at 12:08 pm
(50) Marie S. says:

This is my second round with Savella, first, I started with the 2 week trial, on the 6th day, I woke up and did not feel like I needed the norco or Soma. But a few days later, I thought I was coming down with a stomach virus or that that Savella was making me extremely nauseated. So I stopped it. 2 weeks later after I was over the virus, I guess, it all passed, I got another prescription for the savella to try again, for a few days it did help tremendously. I am now about 4 days into it again, i take 50mg @ night and 25 in day. I really think there is a difference. I seem to have more energy and I can manage to get out of bed without taking norco and soma first, but I have notices awful night sweats. but you know what, i will take that any day if it means I can function without wanting to cry. My big concern is, how long will it work? Neurotin and Lyrica only worked for a few weeks and a few months, but I will take what I can get. 1 thing I have learned about Fibro is that each med reacts differently on each person and I have not found 2 people who benefit from the same regimen. good luck to you all.

August 6, 2009 at 1:40 pm
(51) Ross Phillips says:

Just started Savella yesterday. Very glad to see that it seems to help many with minor side effects. FMS 10 yrs – tried it all, now taking Ultram and Xanax daily along with OTC Aleve and Tylenol.

Blessings to all here.

August 8, 2009 at 4:14 pm
(52) MarciOK says:

Well Ross it sounds like we are in a similar place. I started Savella titration pack on 8-6-09 also. I stopped cymbalta 60mg cold turkey the day I started Savella. Feeling very weird and blurry, after checking out side effects of cymbalta withdrawal I think it may be one of the big problems. My head hurts and shoulder neck triggers are going wild. I have trauma related Chronic Myofascial pain. Darvocet and xanax are 2 drugs that I use very cautiously. Darvocet no more than 3xs a day xanax even less. Although I am in more pain I am afraid to mess with my brain any more by adding a dose of darvocet. I am going to try to keep moving with gentle activity and drink lots of water. Many sites recommended the water. I will take into consideration the supplements mentioned, but I am going to add omega 3 tabs today and try to limit refined sugar. The bad thing with lyrica was an appetite change and added 20lbs over a year, then cymbalta for over a year and no weight loss after discontinuing lyrica. Now I see that weight gain is a side effect for cymbalta.
All I can offer is encouragement to hang in there. All of these real medical issues mentioned are just now being recognized as legit, new treatments are increasingly being found and approved.
Life is good and we can participate.

August 10, 2009 at 2:29 pm
(53) Vicki says:

I have been on Cymbalta as an anti-depressant for a couple of years now and it works well for that. Didn’t do anything for the Fibro pain and chronic fatigue. Narcotics barely take the edge off and I hate the way they make me feel. Doc and I tried Lyrica but the side effects, swelling in my legs and hands, were too severe. Have been on Savella for just about 2 weeks. Don’t see the improvement I did right away with Lyrica but the side effects are barely noticeable. I get flushed and sweaty not long after I take it but it doesn’t last long and goes away completely! So far so good!

August 18, 2009 at 2:06 pm
(54) MarciOK says:

Vicki, I was glad to hear that the Savella sweating only lasts a while. I have been off Cymbalta and on Savella almost 2 weeks. Withdrawal from Cymblata was the worst and those side effects are almost gone. I am feeling more like myself, have started to return to normal weight. I was wondering if it is ok to take cymblata and savella at the same time? My Dr. said no and that was what the literature seemed to say.
Marci in OK

August 20, 2009 at 3:01 pm
(55) HLR says:

My neurologist prescribed Savella for pain and migraines.

I’d be interested to hear from others and if it helped to eliminate/reduce their migraines.

August 21, 2009 at 5:38 pm
(56) coco says:

I have been on Savalla for 2 weeks now and tapered off Cymbalta 1 week and don’t notice the absence. I do have lightheadedness, heart palpitations and blurry vision. I have a real sensitivity to drugs so the first week I took the little tiny blue pill once a day. I am up to the white pill once a day but donn’t think I can go any higher because it relly is making me hyper. Which actually is good because my fatigue is much better. So is my pain. Not gone but better. I’ve had some kind of immune disorder (RA or fibro or both – my doctors can’t agree) for 7 years now and I know what some of you are going through. The “I can’t stand this another minute” feeling is something I’ve experienced.
I will continue on the Savalla for now but I still think there is a lot of unpleasant side effects. I’m still on Lyrica so maybe that is causing them too.

August 30, 2009 at 1:34 pm
(57) Jesse82 says:

I have had CFIDS/Fibro since 1994, came off Cymbalta slowly, but it was rough. I have been on Savella 50mg twice a day for a month now and it has really helped the pain. No help with the depression, I feel very emotional, crabby and on the verge of tears all the time. Side effects are sweating day and night, stomach cramps, constipations, bloating and a 6lb weight gain in the first two weeks. I was hoping that gaining weight was not a side effect of this RX as I am already 30lbs overweight. I have not had more energy, still sleeping poorly and tired all the time. It’s nice to be without pain, but if the side effects don’t go away, I’m not sure I will continue. Medicare/Humana will not cover this drug at all. I buy 100mg tablets from Costco and break them in half. The 50mg tablets are twice the cost.

Anyone else experience weight gain and did it go away?? I wish I had the $$ and energy to take water aerobics to help take the weight off.

September 21, 2009 at 10:29 am
(58) moominmom says:

Hello,
I have been on Savella for 2 weeks and was advised by my Dr. to take 2 starter packs and take twice as long to introduce my body to higher levels of the med. Side effects are sweating, heart racing, and constipation. So far, the only improvement has been a slight reduction of pain. I will continue and hope for the best.
Cymbalta was a living hell to get off of and I recommend a very slow weaning to anyone considering it. Lyrica was terrible because of a rapid weight gain, and I think anyone with Fibromyalgia will increase their pain with extra weight. That stinks because so many of the meds add some pounds.
Fibromyalgia ruins the quality of life, I keep praying for that miracle because I feel more sorry for my loved ones living with me than for myself:(
Good luck to everyone, hope we can all keep posting updates on this new drug!

September 21, 2009 at 11:46 am
(59) ginacarson.com says:

Folks, you CANNOT take Ultram with Savella! Very, very bad. (Dr should have said this out loud before starting!)

I’ve been on it 4 days and feel nauseas and fidgity and still have all my aches and pains. Also had serious migraine most of last week, woke up three days with dreams about having headache and actually had headache! I assume it is from the Savella, as nothing else has changed.

Daily I take: Flax Seed 2000mg, Magnesium Citrate, Antioxidant Cocktail, Vitamin C, Vitamin D-3 1000 I.U., Acidophilus w/psyllium, and L-Lysine 100mg.

I’ve been taking Flexeril & Ultram as needed. They work for the immediate time. I’ve been on Dapsone for six months and do not feel it’s doing anything. Prednisone for flare-ups (I get wicked mouth ulcers since my tonsils were taken out 17 years ago.)

Been reading about hGH and I think I am too young for it, but my mother isn’t. I feel this could be as close to a cure as possible, yet most doctors don’t bring it up as a treatment.

September 21, 2009 at 2:46 pm
(60) Adrienne - Your Guide to Fibromyalgia & ME/CFS says:

Gina,

I hope you’ve talked to your doctor about these side effects. Your migraines sound like the ones I had with Lyrica, which were the worst pain I’ve ever felt (quite a statement from someone with fibromyalgia!) If you do decide to go off of Savella, be sure you get proper weaning instructions — it’s dangerous to quit suddenly.

September 21, 2009 at 1:11 pm
(61) ginacarson.com says:

I believe Savella is giving me migraines. I want to give it a chance. But I also feel odd. My doctor said, “If you don’t feel any better after 2 weeks, stop it.” I would stop it now, but feel I should give it a chance.

September 22, 2009 at 7:09 pm
(62) SUSAN says:

AFTER BEING IN A REAR END COLLISION FOR THE THIRD TIME, WITHOUT SURGERY AS AN OPTION, I HAVE USED FENTENYL LOLLIPOPS, WHICH JOHNS HOPKINS RAISED HELL ABOUT, THEN ON TO OPANA, ALONG WITH MAX DOSE OF LYRICA, WITH SKELAXIN, AND OXAPROZEN, NOW ABOUT TO ADD SAVELLA, FM WAS JUST DIAGNOSED AFTER AN EPISODE OF MY MUSCLES DRAWING TO THE POINT OF NEARLY BUSTING OUT OF MY SKIN, PRIMAL SCREAMS, AND UNCONTROLLABLE AGONY. I CAN SLEEP ONLY A FEW HOURS AT A TIME, THE SMALLEST TASK LEAVES ME EXHAUSTED. THE BEST I FELT SINCE THE ACCIDENT WAS ON AN ANTI-INFLAMMATORY DIET. GLUTEN AND NIGHTSHADE FREE WITH ONLY COLD PRESSED CANOLA OIL USED. AFTER THE EXORCIST PAIN EXPERIENCE IT WILL BE A LONG TIME BEFORE A PIECE OF WHEAT OR NIGHT SHADE TOUCHES MY LIPS. I DO CHIROPRACTOR, ACCUPUNCTURE, REFUSE TO GO TO ANOTHER PAIN MANAGEMENT DR EVER AGAIN, HAVE BEEN TO 5 OF THEM, THAT WAS ABSOLUTE TORTURE, ONLY MADE ME WORSE. HOPE THE SAVELLA, AND MAGNESIUM OXIDE DO THE TRICK WITHOUT MANY SIDE EFFECTS. CHEERS!

September 26, 2009 at 1:58 am
(63) Cathy B says:

I was interested in the comment by Susiedal about Effexor causing sweating. I’ve never thought that may be the cause. I’ve been taking Effexor for a long time and I didn’t always have the unbearable heat and/or dripping sweat. Do you have any more info? Thanks.

September 27, 2009 at 11:35 am
(64) FRAN says:

Thanks so much for this site!!!!!It is such a comfort to be able to read similar & informative stories.I was on low doses of Prozac & Amytriptiline and was so fortunate to go into a “remission” for yrs.(I was diagnosed with Fibro. over 10yrs.ago)Came back fierce 2mos ago(who the hell knows why)nowweaning off Lyrica(didn’t seem to relieve pain & added bonus of 10 lbs)5th day of Savella trial pack(super sweats but much less tired)Pain still there so far, but-so is the hope(that this new Savella drug will work.)THANKS AGAIN for all the comments & stories you’ve all shared.They are a great source of information & also comforting to someone who has similar “pain & depression caused by it”.I will continue the Savella & I’ll continue looking forward to everyone’s personal stories.Keep the faith & keep trying all the new offerings for this “odd situation”we’re all in.If it’s any comfort-at least you, know you’re not alone.THANKS AGAIN!

September 27, 2009 at 6:06 pm
(65) Liz says:

Nurses sometimes are the worst patients. I am an OR nurse. I went through years of pain,(constant dull burning with ocasional sharp shooting pains down my right arm, some numbness and tingling, but rarely. the worse of the problems was the lower back where i also had a constant burning in my lower back with sharp shoothing pains into both buttoks and down the right leg,lots of intermittent numbness, tingling, stabbing in my foot) from a car accident in 1/2006 that i “dealt with” until the symtoms worsened i couldnt take it anymore in 1/2008. Went to a pain management dr and started with an MRI of my neck, showing 2 bulging discs and severe muscle spasm, I had no curvature of the spine that should be there.The dr wanted to do epidurals and trigger point injections, I wanted a second opinion. Next, to to Spine Specialist. Prescribed physical therapy, and some flexiril and said thats all he could do for my neck. Next concerned with my lower back he ordered an MRI of my lower spine, that was never ordered by the doctor that treated me following my car accident. Surprise! 2 herniated discs, L-4 L-5 and L-5 S-1 both comproising the left exiting nerveroot. Again, PT this time some Skelaxin since the flexiril did nothing but make me sleep, and a referrel to a neurologist. Inconsistent neuro but basically “within normal limits”. This doc decided I needed an MRI of my hip since I had almost abnormal results and my complaints of groin, joint, buttock and leg pain. Labral hip tear. Constant refferal from doctor to doctor every test showing something but nothing “major”. Until I injured myself at work this year moving a 450lb patient, landed a trip to the ER. Finally now the pain is being taken seriously. After months of solumedrol, percocet, valium, prednisone, oxycontin increasing the doses…continuing PT for the 8 millionth time.I got a little better as I always do with PT, but then i regress after a few months. Went back to work after 2 1/2 months, apparently too soon, since I was only back at work for 3 weeks 12 1/2 hour days. I couldnt make it through a single week without leaving early because of the pain. Back out and still currently out of work. My physchiatrist, the only doctor that REALLY listens to me, I guess its his job, decided to put me on Savella. I have been taking Wellbutrin for years and had just recently lowered the dose before the work accident because things were so good in my life and I wanted to try life without drugs. Apperently not in the cards for me, but the Savella has shown some promising results. Decreases the need to take anything stronger than motrin or aleve for the pain. I just hate the dry mouth! I’ve also noticed an increase in my BP and get hot easily, I used to always be cold. Other than that I am pleased thus far.

September 29, 2009 at 7:09 pm
(66) grandma wendy says:

Thanks for all your comments. just diagnosed this year am allergic to lyric trying savella today I’ll admit I’m scared the lortab and ativan helps when pain is worse. I try not to take anything. The fibro-fog gets me the worst.

October 1, 2009 at 2:23 pm
(67) Nener Estes says:

I’m on 50 mg a day for fybro and/or lupus. My fatigue was so bad I could bearly hold my head up, but within two days of taking Savella I was wide awake. It’s great for energy level and brain fog. It does make me sweat more and does nothing for pain. I love the stuff, but may have to discontinue it due to the exorbitant price.

October 11, 2009 at 1:06 pm
(68) annie b says:

I’m on 50 mg daily, supposed to take another 50 mg at night but it causes me severe insomnia, may try 100 mg in the morning only. I take it with food. It does help with my daily pain but its effects wear off by mid-afternoon. I still must take flexeril, fioricet (headache), and darvocet for the muscle spasms & pain management.

October 11, 2009 at 9:33 pm
(69) Francine says:

I’ve been on Savella for 6 days now. It has honestly been horrible for me. My blood pressure has gone from normally 110/70 to 150/95 (around there). My resting pulse is way up anywhere from 90 to 130 bpm. I feel nauseated, lightheaded, shaky, like I can’t stay awake (almost like I’m going under general anesthesia). I feel extremely depressed, scared and hopeless since starting the Savella. Should I stop now or wait until I see my Doctor and give it a longer try? I really had high hopes for it. I have had Fibro for 5 yrs. and the most relief I get is from Vicodin (Norco). I need 3, 10/325 at a time to get some relief and it is short lived. I take Lyrica which seemed to help at first with arm pain, but after a few months the pain started to break through. I use moist heat, ativan, and get massages from my supportive husband, but I feel completely desperate at this time. Any suggestions or advice will be taken with much appreciation. Thanks. Francine

October 12, 2009 at 6:48 pm
(70) Adrienne Dellwo says:

Francine,

Check with your doctor about the side effects you’re having. Some side effects tend to go away with time, while others require that you wean off of the medication. Whatever you do, don’t go off the drug too quickly, as it can be dangerous.

Best of luck to you!

October 13, 2009 at 7:16 am
(71) Linda says:

I have been on Savella for several weeks now…it is the first thing that has helped my pain in 15 years!!! My Doctor had said it would take 5 to 6 weeks to build up in my body and start helping. No major side effects (very mild nausea on occasion…be sure to take after eating) and it seems to help with weight loss (a very nice thing). I am currently on 50mg twice daily. I still have to be careful not to “over do”…and I am still tired at times, but it is GREAT not to have that terrible pain. Hope this lasts.

October 15, 2009 at 1:17 pm
(72) Lorraine says:

My 17 year old daughter has been on Savella for a week. She has noticed a difference already but I cannot accept that she will need to take this medication (50mg) twice daily to maintain a quality of life. This condition is so frustrating. Sleep disorders, GI problems, fatigue, brain fog, mood swings, joint pain/TMJ. So many specialists, all want to prescribe a med related to their specialty. Our PCP prescribed Cymbalta last year and my daughter had severe nausea/vomiting and had to stop the med. We have found Savella to be most effective so far but its not a cure-all. And the doctor stressed NO alcohol use with savella(will cause liver damage!) While I know my daughter does not drink alcohol currently, she admitted to using marijuana on occasion and gets some relief from this as well. This is sad but true. She is not a bad kid. She struggles to maintain high honors but misses school alot. She is preparing for college next year and I dont know how she will manage a schedule with this condition. We are going to a Fibromyalgia and Fatigue Center that opened in our area. I have read good things about them. I need to explore the REAL cause of this condition and find CURATIVE methods if they exist, which doesnt seem realistic I know. Its just that these doctors want to tx the symptoms and not fully explore the causes (ie: viruses, metal, yeast overgrowth, lymes, adrenal and/or thyroid disorders). Supposedly this center has many positive results. ANyone here tried them? As for Savella, will keep up the med for now and keep our fingers crossed.

October 16, 2009 at 2:23 am
(73) Trista Ann says:

I began a trial pack of Savella a little over three weeks ago, I have FMS and numerous failed knee surgeries to provide enough pain to also require a narcotic pain reliever, as well as paxil and gapapentin. Please!!!!!! Be careful when beginning Savella. It lists nausea as a possible side effect so i continued taking it. That is until the pain in my stomach was the worst I’ve ever felt and even after not eating for an entire day I experienced dry heaving to the point of passing out. I ask you all to be very careful with this medication. I stopped taking it day 11.5 and will never again take it. My Dr. said that I should probably have been admitted to the hospital due the the severity of my allergic reaction.

October 16, 2009 at 2:21 pm
(74) melissa says:

Is anyone on Cymbalta and Savella? My doctor advised me it was okay to take both. I read a post that says it’s not..? Really need releif from the fatigue and pain, and not looking forward to weaning off the Cymbalta…

October 16, 2009 at 4:49 pm
(75) Kristy says:

Some of my friends have tried Savella. Some of them have had good results with it but one of them did not have a good result. She had to get off of it because it bothered her stomach so much.

October 16, 2009 at 5:23 pm
(76) carol coons says:

Having been on ssri’s for 12 years, I will never get into that again. I am trying to ditch the habit right now and it is difficult; I have read nothing positive about savella; I have seen a few articles. (Red code) and Best pills, worst, pills and they are very negative….I have traded my ssri’s in for acpuncture and behold a miracle. Just be aware that it is not a quick fix like a pill but it does happen with committment and an open mind and no side-effects which always seem to indicate taking another pill to help with the side-effect of the first pill…..try the needle…

October 20, 2009 at 6:55 pm
(77) Adrienne Dellwo says:

Carol,

I’m with you on the acupuncture! It’s done far more for me than any medications. I’m to the point where I only need a maintenance treatment every few months, and in between my symptoms generally stay at a manageable level.

October 16, 2009 at 9:18 pm
(78) striley says:

I have both CFS and fibro, but the thing I most want help with is the foggy thinking. I have been on Cymbalta but my doctor started me on Savella last week after hearing from a GP that Savella helps with foggy thinking. I am going on Savella and he’s slowly weaning me off Cymbalta. Hope it works. Good luck all and God bless.

October 17, 2009 at 3:32 am
(79) Bobbi Beck says:

I’ve had CFS for 25 yrs. & Fibro. for 8, & am completely disabled. I have asked my PCP, 2 Neurologists, & a Rheumatologist to let me try Savella, but none of them had even heard of it. I printed out info. on how to prescribe it. My PCP said he’d research it, but later said he won’t prescribe it because he isn’t familiar with it. I just don’t have the strength to keep trying to find a Dr. who can help me.

October 17, 2009 at 7:54 pm
(80) melissa says:

I tried Savella, and about a week into the trial, I started experiencing very disturbing side effects. I was sleep walking, hallucinating, talking to people (that I could see) who weren’t real and doing things when I was sleep walking that I didn’t remember at all. I would open the refrigerator door and stand in front of the open refrigerator for 30 minutes at a time; I woke up my husband several times to deal with people in our kitchen that had things that belonged to me – I even got rid of appliances and cut cords on others. I ended up going to the hospital about a week and a half after I started taking Savella as a result of an infection and electrolytes that were very out-of-whack; it took about three days of discontinuation for all of these symptoms to finally go away. I have talked to others who have experienced these same symptoms with Lyrica and Cymbalta as well. I just know that Savella is not for me.

October 17, 2009 at 9:25 pm
(81) Heather says:

Using a combination of Lyrica 150mg and the last five days on a trial of Savella working my way to 100 mg a day on that, so far, i have had more energy, less pain, and am taking less of my Tramadol and muscle relaxers. the whole point to taking both meds was to cut back on the other pain meds, i hope it continues with the same results.

October 18, 2009 at 7:26 am
(82) Charlie says:

I was diagnosed w/FM about 2 yrs. ago and have been on Cymbalta, Neurontin w/o good results for pain. I have been on Savella for about 2-1/2 mos. and am pleased with the results. In the beginning I experienced severe sweating (profuse) but has decreased sig. now. For me it took about 1-1/2mos. for Savella to start working to it’s potential so my advice is to try to stick it out for a while, because it may just be your answer.

October 20, 2009 at 12:16 pm
(83) amber says:

I have also had the vein popping feeling with fibromyalgia. I told my dr. my veins hurt and it feels better when i rubbed them and he said it wasn’t a fibro symptom but then the next time I went in he said it was a normal fibro symptom. I have had a vein burst in my finger without even any trauma and it turned all black and fat. Savella has helped me alot I take 50 mg. in the morning. I have alot more energy, less appetite, and I can deal with the pain better. It is not all the way gone and I still have bad days, just not as many. My vein and arthritic type problems are still the same. It is a godsend to me and I have tried most of the med’s out there. Lyric made all my nerve pain worse and it is scary trying a new medication but am willing to keep trying since my children are all small and I need to function.

October 20, 2009 at 4:22 pm
(84) Laura says:

I have been on Savella for 4 weeks and not having fun, I have nausea, migraines (the worst symptom), dizziness and diarrhea. I was on Cymbalta for years and it worked great, but seem to have developed an immunity to it this year and have had 3 bad flare ups where I had to take Oxycodone for pain. Trying to back off of the 50mg Savella dose and do every other day, then try 1/2 in the am and 1/2 in the eve….I would rather have fibro pain than these migraines.

October 21, 2009 at 12:42 pm
(85) Bobbi Beck says:

I am having trouble finding a Dr. who is familiar w/Savella. If you know of someone in MA, please let me know!

October 22, 2009 at 12:27 am
(86) K... says:

I have read everybody’s comments & thank you for you posts But, I have not come across Anyone who has taken Methodone pills. I have FMS/CFS & more back-disk-spams – TMJ-sciatica The list goes on – Anyway my Pain management Dr. wanted to suggest Savella however I have a very severe case as U can tell by the med’s they have me on- I dont take anything else I dont do drugs or drink- I have a very high tolorance for pain -(I danced with a broken collar bone & was boxing with torn tendones on my wrist) I didnt know it at the time – So what I am trying to find out is- If Savella IS helping some people – who were getting by on OTC medication – what can it do for me? i have read where some of you were on some heavy med’s but got no relief from Savella – I doubt it will help me-
I did get so great tips from this site & ur posts so thanks for that. WHATEVER U DO – DO NOT let them put U on A Duragesic/Fentanyl patch – People Died & I lost all of my teeth & it messed up my kidneys/Liver – DONT TAKE IT!!!!! I am about to try this proceedure to help with ALL of the muscle knots my body is infested with them wherever there is a mucle I have them Even in my Jaw! I heard MicroVas – can help – I have an appt in 2 weeks -Ill let everyone know how is works out. Good Luck to ALL

October 22, 2009 at 12:26 pm
(87) Rebecca says:

It took about a month and a half but there has been been a marked improvement. For the 1st time in many years, I CAN WALK UP STAIRS! Not pull or push myself up them, but actually walk up. I still need to be mindful not to over extend myself, but generally I feel much better. Had some minor problems initially with irritability and occasional wave of nausea but those symptoms are gone now. I couldn’t take Cymbalta or Lyrica sufficient to be effective because of the fluid retention which made my Asthma worse. Finally, something that works without the weight gain and breathing problems. I haven’t felt this good in at least a decade.

October 23, 2009 at 4:34 pm
(88) Annie says:

My RH has been treating me for 10 years. He told me to stay away from any drug marketed for FM. Drug companies are just trying to make money off of us.

Pain meds, supplements,exercise and common sense works for everyone.

November 16, 2009 at 3:10 pm
(89) nlightened says:

I’ve read so many of your comments on how Savella is helping you and am glad that you are having success with your pain management. However, I feel compelled to share my experience with you so you will be informed of severe side effects should you start experiencing any symptoms.

November 24, 2009 at 2:12 pm
(90) debbie says:

I am currently taking Savella and Cymbalta together although not recommended as I was weaning off the cymbalta and onto the Savalla I found that at 60 mg of Cymbalta and 50 to 100mg of Savella my feet stopped hurting so much, I can get out of bed, I have more energy and alot less pain. When I came completely off Cymbalta and just on Savella it was not really working so my doctor said since there was no adverse side effects if it is working he will use the combination. I also take Zanaflex for muscle spasms and Restoril for sleep and it is all coming together where I can actually function. Somedtines you have to be persistent and try new things and combinations since everyone is different. Before this I would cry in pain, but I am at a place where I can tolerate the stiffness and low pain.

November 27, 2009 at 1:26 am
(91) Jennifer says:

I have been on Savella since August. It has been a wonder drug for me. I had had severe muscle pain for nearly seven years. I often felt as if I had the flu. I had severe, chronic, migraine headaches, and jaw pain that would leave me feeling nauseous and depressed. The knots in my back were NEVER relaxed. I took the titration pack of Savella at the recommendation of my rheumatologist. It made me really sick to my stomach at first, but the nausea subsided. I was on it for nearly a month before I began to feel better. I feel like I have my life back now. The knots in my back are not nearly so tight, my pain has markedly diminished, my migraines are completely gone, and my energy level has increased. I had always had so much energy before the fibro basically robbed me of it. I finally feel good. I take zanaflex and naprosen everyday in addition to the Savella, but these treatments have really helped. I read a post earlier about OTC’s not helping, so how could these meds. Well,none of the OTC’s I took put a dent in my pain. I could just as well have taken sugar pills. Nothing helped at all, no muscle relaxers, no advil or tylenol, and really no pain meds, which I couldn’t take and function anyway. For me Savella has been a miracle drug. It’s not an anti depressant, it’s specifically for fibromyaglia , and boy has it helped me. For those that are suffering out there, don’t give up. This syndrome is finally being taken seriously, so if Savella doesn’t help, I bet there’s something coming that will. Take care all.

December 1, 2009 at 8:18 am
(92) Terri says:

Just was prescribed Savella haven’t started it yet. Diagonosed with FM finally after years of trying to convince dr.s there was something wrong. I scored 16 of 18 tender points…plus a variety of other symptoms by history that finally someone said, “I think you have fibromyalgia”. Thank God someone finally said something. Have tried Cymbalta but it didn’t do much besides make me sweat and I believe give me gastrointesinal problems which I already had. I use Ibuprofen, sometimes Flexiral and Darvocet for pain, will give the Savella a try. (Fingers crossed) Its a very frustrating illness!

December 4, 2009 at 1:29 pm
(93) mstriley says:

Savella has helped me more with foggy thinking than anything ever has. The pain not so much, but I am very grateful for improved thinking.

December 5, 2009 at 9:28 am
(94) CeCe M. says:

Was on Cymbalta for about a year and a half. I felt better but not enough to put up with side effects. I was off Cymbalta for a few weeks dealing with withdrawl and tried Savella. Just finished thetrial pack. It definietly helps me. Feeling much better and the sweats seem to be abating a bit. Night leg cramps have become more of a problem but I am hoping this will also work it’s way through. My daughter has RA as well as Fibro and is currently weaning from Cymbalta due to the same side effects as I had on Cymbalta. She is going through a very very difficult withdrawal but is almost on the other side of the peak now so she is hanging in there. I know weaning is difficult but dealing with the pain and exhaustion is not an option either. I still have pain. I am not “normal” but I can enjoy life and the activities I love. As the medical community finally addresses Fibro as real more help will come. My mother has suffered for years and years with Drs. telling her it is all in her head so we ARE moving forward. Savella is great for now. No other option but pain.

December 11, 2009 at 10:13 pm
(95) Allisa says:

I am scheduled to see Dr. next Friday to discuss Savella. I am currently down from 10 mg of Ambien each night (hated not knowing what I would do on it) to 5 mg (which I don’t wander around on), Gabapentin 600 mg at night (not sure it does anything) and Hydrcodone (now up to about 24 mgs a day). Everything about me has changed; I have no tolerace for anyone anymore. My pain makes me so angry and trapped. The only med that reduces without side effects is the Hydrocodone and my doctor said my level on that is getting dangerous. Honestly, I do not suffer from clinical depression but I find myself wanting to scream or cry and I just hold back from doing either. I truly hope this works because I am so exhausted with trying medicine after medicine and juggling the side effects for each. I will get off the pitty-pot now, but my frustration/pain has seriously changed who I am.

December 16, 2009 at 5:50 pm
(96) AnnaMarie says:

I just started taking Savella yesterday. After trying Cymbalta for 1 year and having swelling of face and hands my Dr. took me off. He put me on another antidepressant and I was really allergic to that one. That one made my lungs feel burnt and breathing was affected. Had a hard time stopping the other meds because my Dr. stopped me too fast becuase of the allergy. Hope Savella works,,,really bummed out!

December 25, 2009 at 4:43 pm
(97) Ann says:

I know that most of us have tried more than our share of meds for our “ills”. I think what we all have to remember is everyone’s body is different what works for one of us, will not work for the next. What helps one of us will make the others pain worse. I have tried so many meds over the years I honestly can’t remember all of them. I felt that Savella made me more depressed but it’s hard to know if it was just the Savella or “life situations’. I would like to try it again though, maybe in a year. I really think that for mome of us the key is really trying it in a pediatric does if the med can be safely split (not long acting). I know that I have had Fibro since I was 5. Was in the hospital for unexpainable pain at that age and they though I had RA. As I got older and the tests came back neg., it was unexplained at the time. Not until 41 did I actually find out what the problem was, and then no one seemed to know what to do about it. Thankfully now I have a doctor that does believe it exists and is willing to treat for pain. I think that all docs should be required to take pain education as continuing education credits. It’s all changing so fast, and I really wish that there was a way to make them feel the pain that we feel 24/7 that would bring about some changes real fast. I think that if they dealt with what we deal with 24/7 for a week most of them would be like crying babies. We smile as much as we can, and people sometimes don’t even know we are in pain, because we are smiling. I really want to slap those people that doubt it exists. Yes, I wasted my time and money going back to school at 38 to find a new line of work because I am “lazy and don’t really want to work” I would give anything to be able to return to work. I am isolted and the people that I thought were “friends”walked away when I could no longer keep plans that I had made. Gee, I can’t go out and have fun? Do you think maybe I am sick enough that I can’t work? HELLO!!! To all of you, I wish happy holidays, health, and happiness for the new year!!

December 25, 2009 at 7:34 pm
(98) Cheryl says:

I’ve had CFIDS for 23 years. I knew I had “sick muscles” but thought it to be a part of CFIDS. I was surprised to be diagnosed with FM as a 10+ out of 10. I was prescribed Savella in May 2009. It is a definite love/hate relationship. It has handled the chronic pain to the point of being able to sleep and do more housework (trying to keep from falling into a deconditioned state) but the side effects are unpleasant. I went from very restless sleep to solidly sleeping 12 hours a day…during the day, and being awake all night long. That lasted nearly 6 months. Eyelid and limb muscles still twitch, empty stomach still causes nausea but not as intense as before, continuous ringing in my ears hasn’t changed since I first started taking it, and constipation was a big problem for the first 6 months. One thing that was quite remarkable was after my second dose, the brain fog I’ve had for 23 years vanished and hasn’t returned.

December 25, 2009 at 10:04 pm
(99) Athena says:

I am new to my diagnosis; and I can tell you for me.. the Lyrica seems to help me the best; so far. I am soon to start Cymbalta in that mix too; and have two different kinds of PT ordered; and might add water aerobics in that mix.

Before the lyrica the “tinglies” as I can them (including the RLS) were UNBEARABLE.. but they drop from a 9 to a 2 with it. I also take .25 xanax – .5 xanax 2 times daily for PSTD/Panic/Anxiety disorder I had prior to the FM or CFIDS or whatever I have that is going on. I am hoping the Cymblata works for the mood. Without the Lyrica; I wouldn’t probably eat. i’m overweight; but the IBS/Acid reflux and nerve issues I experience without the Lyrica.. prevent me from eating! when I take the Lyrica I actually have an appetite; so it’s a much welcomed side effect compared to the others. =)

So far so good. Nothing is perfect. My worst symptom is tinnitus (ear ringing). If any of you have this; and have found any med that helps with that.. not helps you to tolerate it.. but helps it to go away/lower in level – PLEASE POST AND LET ME KNOW!! I supposedly have it due to overstimulation of cranial nerves (much like FM is overstiumlation of nerves).. that this carries over into cranial nerves for some of us. I’d give anything to have some relief from this =)

December 30, 2009 at 5:36 pm
(100) gtarmike says:

I have filed for disability and have to try whatever my doc recommends, so I tried savella even though I have tried cymbalta and got nothing beneficial from it and really didn’t want to take another antodepressant. Doc gave me a trial pack. After 1 day I started having difficulty urinating and the second day it almost stopped completely. Doc said I wouldn’t be able to continue it.
I have been on tramadol for years and it is the only thing that has helped. Still have a terrible time sleeping, use ambien on occaision but it becomes ineffective if used too often.
As for what causes this nightmare, I feel like XMRV at least makes sense where no previous “explanation” ever has, and I hope something comes of the research into it.
PFDAN, friends (pain-free days and nights).

December 31, 2009 at 11:58 am
(101) TonyV says:

I had been taking prozac almost two years for fibromyalgia, finally ended up taking 60 mg a day, which worked well for my pain. However, prozac did nothing for my chronic fatigue. I started savella 11/17/09, stopping prozac 11/22/09, now taking 50 mg morning and night. It seems to take away my pain equal to prozac, and I find myself not needing that late afternoon coffee as much & getting out of bed in the morning without that ‘drugged feeling’ that I had while taking prozac. However, I now have headaches, some nausea, and severe pain in my left nostril (which is entirely new to me). These may be due the cold weather that has moved in. I don’t know. My plan is to ‘hang in there’ with savella a while longer to see if those symptoms end. I also have developed severe pain in my hands, particularly my thumbs. I do not know if this is related to anything, as I am 65, live in the country, and am very active in doing whatever needs to be done – from cutting & hauling wood for our stove to fixing whatever needs fixing.
Thanks for any feedback.

January 13, 2010 at 10:43 am
(102) Molly says:

I took the very first 12.5mg dose and felt like Linda Blair in the Exorcist. I was so anxious that I felt like my head would start spinning around and I would start levitating. Cymbalta caused me to be more anxious after about a month of use, but it was nothing that Hydroxyzine could not help calm. I also have RLS, so when anxiety is heightened, my legs go into helicopter mode.

January 21, 2010 at 11:53 am
(103) Sherry says:

I recently tried Savella and it did not help my pain. Also, my angina worsened and I had dizziness and nausea as side effects. My physician, however, reports that it did help one of his fibromyalgia patients to the extent that she no longer needed narcotic pain medications.

January 22, 2010 at 3:46 pm
(104) bmotor1 says:

I have been on Savella for almost a year. I believe my pain level has been better since I have been on it and I know my mood and quality of life is better. I think it should be left up to each individual to decide whether they want to take it or not. You cannot judge the pain or depression of another person to know if the side effects are too great for a person to take the chance on. I DO NOT WANT THEM TO TAKE MY SAVELLA!!!

January 22, 2010 at 3:48 pm
(105) Bobbie says:

I took Cymbalta for over four years and it was a nightmare! I am now taking Savella and it has improved the quality of life immensely. I am also taking several pain medications and have been able to cut back on the amount I need. I have more energy than I have had in years, also have an appetite and better quality of sleep. I do still have some bad days here and there but not every endless day & for the first time in ages I don’t wake up in tears wishing I had not awakened. If they were to take this med off the market I would be devastated! I have tried so many different anti’s and other med types and I can honestly say this is the first that has ever given me a ray of hope for any kind of life.

January 22, 2010 at 7:22 pm
(106) Judy Makowski says:

I have been on Lyrica and Savella for several years and have had no bad experiences with it. My dr. had to raise the amounts until they were at the proper dosage to help me. They have helped.

I’m not saying the pain is gone but it helps to take the edge off.

January 31, 2010 at 1:30 pm
(107) Linda says:

I am currently starting my third week on Savella, and it is already helping my fibro pain more than I ever expected. I have had fibromyalgia for 20 years with not prior relief. My daughter is also on Savelle for 2 months now with the same great results. She’s had this longer than me! Pain is gone, a feeling of renewal and much hope. More energy also. This is the only med that has worked well and should not be pulled from the market. I have been on med to control my blood pressure and heart rate, and have had no increase in either being on Savella. Guess it should be evaluated for each individual by doctor, but definitely not unavailable for all to try to control the suffering.

February 6, 2010 at 10:57 am
(108) Meg says:

I was diagnosed with fibromyalgia a few years ago. My internist put me on Cymbalta, which was somewhat helpful (especially with the joint pain). I didn’t have the anxiety side effects some of you have described, but intensely disliked the emotional blunting I experienced. Also, I was concerned because my doctor didn’t seem as interested in doing diagnostic tests (RA factor to check for rheumatoid arthritis, sed rate and/or C reactive protein for inflammation, xrays to check for structural problems in my knees and shoulders) as he was to prescribe the medicine. I eventually become tolerant of it; it quit working. The pain returned.

I am a nurse, and believe that modern medicine is a good tool, but is not the only wisdom out there. Since traditional medicine was problematic, and in an effort to treat my body better and address causes rather than symptoms, I began seeing a highly recommended homeopath. At her advice, (and against my internist’s advice,) I gradually weaned myself off the Cymbalta.

The supplements she prescribed were remarkable at addressing my symptoms and making me feel like a ‘whole person’ again. I had none of the emotional blunting or lack of libido I’d experienced on the Cymbalta.

Unfortunately, a few months into the treatment, we had a crisis with my then 18-year old daughter that plunged me into a depressive episode, and I was faced with hospitalization (which would have been a first for me) or going back on an antidepressant. You can guess what I chose. The psychiatrist chose to put me on Pristiq, and explained to me that Venlafaxine (Effexor) had been the drug used in the fibromyalgia trials and was found to have pain-relieving properties. Pristiq is the purified Venlafaxine, and has less side effects. It has helped with the pain. I do have some emotional blunting and have gained weight, but it’s better than the alternative. (My daughter’s situation has partially resolved, but not completely.)

Unfortunately homeopathy and modern medicine don’t seem to mix. The interaction of the two isn’t well studied or documented, so I’m more than hesitant to combine them.

There are a couple of other interventions I’ve found helpful though. I have a wonderful chiropractor, and regular visits have been very helpful in maintaining flexibility and decreasing stiffness and pain. Walking helps. Lastly, I tried Formula 303, and that helps my body relax (it has valerian, passionflower and magnesium in it.) I don’t take it all the time, just when I need a little extra something.

I hope this is helpful.

February 17, 2010 at 9:24 am
(109) Tami says:

I like what Savella has for me as far pain…but when or does the ringing in the ears go away….its drivin me nuts !!!!!!!!!!!

March 2, 2010 at 11:16 pm
(110) jen says:

I started taking Savella for fibro. I also have anxiety and depression and have been taking lexapro for 3 years. I have had no side effects with lexapro and it works very well. I will never take Savella again, however. Even at very low doses, the side effects are so disabling, I would rather deal with the fibro pain in other ways. I experienced severe nausea, headache/migraine, cold-sweats, anxiety and panic. No thank you. The side effects were so severe that they outweighed any benefit Savella might have provided.

March 12, 2010 at 1:24 pm
(111) sm says:

for Danielle – I too had issues with Vit D, count as 4 with intense muscle spasms. I have been on 50,000 units of Vit D twice a week for 2.5 yrs. Each time we stop, my Vit D count bottoms out again. I drink Soy Milk and Protein shakes twice daily and still drink milk a 3rd time. For some reason, we are not able to stabilize the Vit D count through normal healthy habits. Makes the muscles hurt doesn’t it. You are not alone. Good Luck

March 14, 2010 at 11:18 am
(112) Anne MH says:

Patricia,

I was about to start cymbalta, but saw your comment about allergic reaction due to allergy to ragweed. Ragweed is my main allergy – please help me understand how cymbalta triggered your allergy.
Thank you,

March 16, 2010 at 9:56 am
(113) PaulaJ says:

I’m with Dint who posted about taut muscles. It’s not funny but at least we know we will never lose muscle tone! I agree that narcotic opiods work the best at relieving all over pain, and my physician said I could still take my hydrocodone in addition to Savella which I just began taking last night. No pain relief yet, but my mood is better:)

March 17, 2010 at 5:30 pm
(114) Jane says:

I know someone is is taking Cymbalta for pain for several years and has severe ragweed allergy. So far, no issues except for a frequent runny nose…but that small issue seems to be worth it to them for the significant relief they get

March 23, 2010 at 1:19 pm
(115) Sue says:

I m wondering if Savella helped people lose weight?

March 27, 2010 at 8:17 pm
(116) Patricia H says:

Anne MH,
If you have any questions regarding drug interactions, I always talk to my pharmacist. They have a wealth of knowledge when it comes to drug binding agents and ingredients of the drugs.

March 29, 2010 at 2:23 pm
(117) debbie says:

I have been trying for 8yrs to get some quality of life back after being dx with Celiac disease, Fibro and Dermatitus Herpetaformus. Been to Mayo Clinic 2 times tried every drug they know to put me on tried physcial therapy Savella has been the only thing that has gave me back some of the energy i used to have back BUT I am sweating not seeing well and am very foggy minded with anxiety and depression I dont know what to do it was great for about 2 months then i also had to have a hystorectomy and started on thyroid med do to low scores can someone help anyone else have all this going on? Cant stand being in bed from the pain of fibro but dont know if i can stand all the side effects and i cant find a good Dr. Help!!!

March 29, 2010 at 9:21 pm
(118) Nan says:

58 year old femail with FMS for 27years. I have been on Savella for two months. Previously took 60 mg Cymbalta for several years, and it helped, but I was having increased pain. The two week titration package was a litte rough since I was still on the Cymbalta and maybe was getting too much seretonin. Eased off the Cymbalta during week three. Savella definitely helped the pain, but the side effects are rough for me. The top of my brain feels like it is floating, having mild to moderate headaces, head sweats, frequent dizziness, tinnitus, and impaired cognitive ability. I really wanted it to work, and it did, but the side effects are not tolerable for me. I am weaning off and want to just try neither Savella nor Cymbalta for a while. My doctor has mentioned Lyrica, which I may consider if I feel like the pain is too much in a month or so. My suggestions would be to be careful about getting too much seretonin, maybe try it, but decide if the side effects are tolerable or not. Your case could certainly be different. I also take flexeril at bedtime and use a Bi-pap machine for sleep apnea, both of which are a godsend for getting a good nights slee.

April 6, 2010 at 10:20 am
(119) Debbie says:

Nan I was on Cymbalta for about 3yrs did ok but still had lots of pain and fatiuge but was not depressed then one day started having heart palpations so decided to go off found a fibro speacialst who put me on savella hardly ever have as much pain but the other side effects are overwhelming also have to take thyroid meds and had hystorectomy 3 months ago and trying to take hormones cant tell what med is causing what side effect I feel like going off all of it but at least I can stay up and out of bed!!! If I knew for sure it was not doing damage to my heart may be i could deal with it better.

April 11, 2010 at 11:50 pm
(120) Heather S says:

Every sience i was a little girl i have had bad pain all through my legs they said it was growing pains at first then they tested me for all kinds of stuff but never found anything, meanwhile the pain just got worse and more widespread. so a few years ago we talked about fml. i would like to know if any of you had problems with your legs hurting when you were little or if maybe thats how urs started. i also like most of you on here deal with depression and just not feeling like going anywere or doing anything. how can you your tired all the time and hurt. i have also been on so many diffrent meds its not funny lyrica, naproxen, tramadol, cymbolta, welburtren, and others im sure. now hes trying me on this savella again. i really didnt try it the first time because the last med they put me on “seroquel” scared me i had all sorts of crazy side affects almost burnt my house down. but this time i said screw it and i tried it and let me tell you when i did… 30 minutes later i started feeling weird then it was like i was out of my body or something i cant explain it then “i was laying in bed” i started seeing things and hearing things i was shaking all over, sweating, then i slept like 14 hours. and was still tired all day the next day. and i was so ill. i had really bad mood swings. it was terrible. so needless to say i sure as hell did not take the next dose. the dr. is always saying you have to let it get into your system. yes thats right, but im not going to just keep taking something thats going to make me like that and give me a heart attack. i really think that maybe the reason i have all these issues with depression is because of the pain not the other way around as the dr. obviously think. to me every time they put me on these anti depressents everything gets worse. honestly i have tried it all and the only thing that ever helped was a oxycodone. but the dr. isnt going to give you that. i know that they are addictive but i would really like to be able to live my life without this pain for once. if it helps we pay insurance how about give your patient what the tell you helps. mine dosnt seem to hear me. im getting so tired of having to get up go to the dr. to leave no better thank i was before i got there. he also this time gave me the flector patch and amirx. i have tried amirx before it dose help a little with the spasms in my back, but nothing else. i just like to take one new med at a time so i can be sure whats makeing me feel like what. so let me know about everything and the flector patch.

March 14, 2011 at 10:06 pm
(121) Rachel says:

I saw that in your post you commented about having pain in your legs when you were a child. I had the same as well as my mother. She called them “leggin-aches” I used to get up at night and rub warm water on my legs when I was around 5 yrs old. The pain also progressed with me. It almost became “normal” and I figured everyone was in pain like I was. I have heard that Fibro is thought to be genetic. Perhaps it rears its head early? I agree that pain can cause depression. I have taken tramadol for years and it seems like when I take it and it actually works great, I end up having a wonderful day – full of energy and I get lots of things accomplished. I hope you have been able to find a doctor that is sympathetic and will given you pain meds. I am having the same problem. Doctors are so afraid of being labeled pill pushers. Those who abuse prescription meds make it really hard for us. Good luck to you and your treatment!

April 5, 2011 at 2:43 am
(122) kittykat says:

i to had leg pain and horrible knee pain as a child started around 13 my parents took me to all kinds of dr.s got all kinds of diagnosis. i a dr i saw in my late 20′s said it was fms i at last a name to the horrible pain in my body! i have been put on several diffrent antideppresents(at diffrent time) they were horible i got severly depressed and was hospitalized several times! so no antideppresents for me. i was kinda in a remission until my divorce 2 yrs ago and had to go back to work full time to live! anyway its all i can do to get myself there and home up until the divorce i saw a great dr who had me on dilaudid and soma. no problem with him doing this and for several yrs. any way im back in pain and worse then ever. i had to find a dr i’ve been seeing this one for 2 months i started sevella this evening. i told him mt past he still wanted me to try. he gave a trial pack to start so will see. i also have carpel tunnel and have had surgery but it’s bad again so he gave me 10/325 norco but also told me that narcotics are not indicated for fms and its just a bandaid! i feel if something is working 10/325 and 1800mg of gabapentin keep the patient going. im going to try this but i dont have insurance and unless this helps so tremendously then he and i are going to have to have a meeting of the minds. just dont think i can afford it anyway! he said something about sample packs. what is he gonna do that for the rest of my life! i also dont get these doctors. he is going to get me medical records and maybe that will sway him also! i let you know on bolth!

April 13, 2010 at 6:15 pm
(123) Medi says:

I started Savella a couple of weeks ago and had to quit taking it last night. It gave me severe depression and thoughts of suicide and seemed to make my pain worse. I had weird sounds and flashes of pictures and noises in my head. And no I am not psychotic. This is the scariest medicine I have ever taken!!

April 15, 2010 at 11:34 am
(124) kim says:

I have tried Cymbalta (waking up at 3 am and no relief) and Lyrica (10 lbs. of water weight gain and no relief. Tramadol worked best for me but I am allergic, started developing a rash and itchiness. I take Soma once a week when I know I can sleep 9+hours (still work full time) but I’m not sure that it helps really. Darvocet does very little, take that every other week if my herniated disks start to act up.

I have the trial pack of Savella, been holding onto it for months now but I think I’m going to start it in May. I’m going to read all of these comments and discuss with my rheumatologist next week. Thank you all for sharing your experiences.

April 16, 2010 at 3:58 pm
(125) Renee says:

Diabetic Neuropathy in both feet. Osteo or rheumatoid arthritis, fibromyalgia…..on and on….I have so many medical problems right now,I won’t even go into all them on here. Years ago, I was put on Lyrica and I know it made me gain at least 40 lbs., nothing in my diet had changed and I was even more active! The minute I went off it, I started slowly losing the weight.

Then I was on Cymbalta(both meds for diabetic neuropathy in both feet), and it worked well and I have lost almost 100 pounds, but not because of Cymbalta, I just hardly ever eat,when i do it’s healthy. I have to go to bed hungry (weight problems run in my family, so it’s at least partly genetics). I read that Cymbalta blocked REM sleep. I know that’s not good!

My old doctor told me that wasn’t true, it only applied to some people. I mentioned this to my new doc, who then put me on Savella…no weaning off Cymbalta! I felt nothing while weaning!

However, I have been eating small amounts if at all and have already gained nearly 5 pounds in a week since making the Cymbalta to Savella switch.

Is there any medical proof anyone knows of that makes either of these medicines make a person gain or lose weight? I have to go on the one that encourages weight loss. At this point in my life, I’d rather be dead than fat.

I have always had a weight problem, done the yo-yo thing forever. I have a ways to go yet in my weight loss, I realize it’s a lifestyle. Fat people are the most discriminated people in this country, treated like trash, worse than murderers. I want to lose more weight for my health, and to look good because I’m single now, by choice. I was just starting to look good again, and now I’m gaining weight after eating practically nothing? It’s either a hump i have to get over in the weight loss, or the Savella. I couldn’t be more discouraged to get on those scales after starving and see weight gain….and don’t tell me I need to eat more! I’m doing just what I did to lose the 100 pounds, and now gaining. Your opinions would be appreciated. Thank you. myspace.com/ reneeisonegative

April 25, 2010 at 2:06 pm
(126) Linda K says:

I’m tapering off Savella presently. No difference in pain level while on it, nor while on Cymbalta earlier. Savella did make me sweat frequently all day and night and had a depressive affect on me–teary eyed at times for no reason. I presently take Lyrica and Tramadol for 5 years and found that they make the pain sort of tolerable, if one can call it tolerable! Still hoping for research to tell us, one day, what really CAUSES the pain and how to fix that cause!

April 26, 2010 at 10:03 am
(127) Dawn says:

Almost 3 years ago I was injuried at work. I had surgery to fix part of the problem but am still dealing with nerve pain and issues in my neck, shoulder and arm. I get migrains and have trouble sleeping. I try by best to keep my head held high up it gets real hard some days. I had lost 50lbs before I was hurt and had kept it off for a while but after being hurt and my level of activity being cut back and the types of them I can do, then add a gambit of med’s that had side effect of waight gain. Needless to say that 50lbs is back and I am on to the next med. Savella. I haven’t made my mind up yet.Yes it helps with some of the pain and other issues, but I am really scared of gaining more waight and having another med. fail.

April 28, 2010 at 10:11 am
(128) Carol Robinson says:

I have been treated with about every antidepressant available and I had extreme adverse reations with all of them, the last was Lyrica which made me extremely depressed. I have been on the Savella for for (3) weeks now starting with the titration package and I am now on the 50mg twice daily. The only negative that I have noticed is the dry mouth, and it seems to be stabilizing both my pain and mood swings. In the past I would swing between anxiety/obsessive behavior and depression/fatique/sleeplessness. I’m almost afraid to acknowledge improvement for fear that it’s wishful thinking. However, I must say that the Savella seems to be working for me but it is still early in the treatment stage. Hey, I’ve tried everything else available, maybe this is my miracle RX…..I sure hope so. I’m (60) and I’m really ready for some quality life.

May 1, 2010 at 5:20 pm
(129) Debbie says:

I too have gained since starting Savella and my Dr told me it would not cause weight gain. I have been on it since last July and found it to be a miracle drug for about 3 months now im not so sure having terrible sweats, heart racing, vision problems and now im getting panic attacks back. Im scared im gonna have to go off it and be back to being in bed 3 out of 4 weeks a month

May 1, 2010 at 9:08 pm
(130) suzanne says:

Been on savella and I’m sweating profusely most of the day. Someone here says it stops after taking it for a while. Well, not for me. I’m constantly wet with perspiration and it’s miserable, but NOT AS MISERABLE as I am when I’m OFF the savella. Savella has helped my pain to the point where I am so much better. So, it’s like this…miserable sweating all day, or miserable and in pain. It’s a close call here but I can’t go back to all the pain I was having before the Savella.

May 1, 2010 at 9:10 pm
(131) suzanne says:

The sweating is terrible, but the problem is you can’t go off of it without being in worse pain than before taking the savella. Because it raises our noriphenephrine levels (that is what helps the pain) when you go off the Savella you are more miserable than before taking it. I have to take the Savella, even though I am sweating, but will have to reduce my dosage in half and see if that helps.

May 2, 2010 at 11:45 am
(132) barb says:

Never tried Savella. My doctor gave it to me to try but I went home and read the side effects and this blog and was very concerned. I did very bad on cymbalta and this sounded worse. The next day I had an appt with a doctor at a major university whose specialty is in pain management and he said do not take it. He said it has a black box warning label which I had never heard of before, which I understand means side effects worse than the help it offers to most.

May 7, 2010 at 3:37 am
(133) Hope says:

I was diagnosed finally with Fibro in January of 2010 after long term suffering not knowing what was wrong with me. Besides the pain I found myself in a deep depression and also having severe anxiety attacks sending me to the hospital. I have been on Savella now since January and have found it beneficial in some ways but not others. The anxiety is GONE, the depression is greatly been reduced. The pain is is still there but trust me missing a dose has taught me it is no where near as painful as without it.

I realize everyone has different experiences and reactions to meds..and all results are different you just have to try things till they work the best they can. I do have horrible hot flashes with Savella and it didnt help at all with the extreme fatigue however I have found a great helping aid with my savella I have 1500 mcgs of B12 and 500 mgs of Cinnamon and have found amazing results with my energy levels. I am also a diabetic on top of the Fibro and both aid in Diabetes also..its something to highly consider and the results have been amazing! I also take melatonin before bed as a sleep aid.

My big issue is still controlling the pain more, so I am considering asking my doctor to add Lyrica as a aid to the Savella and see what happens. I was thinking of having her change my neurontin with the Lyrica.

May 16, 2010 at 7:18 am
(134) Christine K. says:

I was diagnosed with fibro 2 years ago after a year off trying different medicines. Lyrica was a joke and made me very ill. I am now on darvocet, nexium, neurontin, celebrex, and just a few days ago he added savella. Not feeling very well. Sick to my stomache and exhausted. Feel flutters in my chest. Do not like it. Will keep trying for a another week. My doctor has never diagnosed fibro before so I feel like and experiment to him. No insurance and laid off. I get some help from the drug companies but it is so hard to make it with the different changing of drugs!! So tired of all of this. Anxiety and depression are through the roof right now. Hoping the Savella will work some after a few more days.

May 27, 2010 at 12:10 am
(135) Shannon M. says:

I have had Sjogren’s Syndrome and fibro for many years. I’ve been on just about everything there is to try to cope; Lyrica helped with the pain but made me so tired that I could not get out of bed, so could not stay on it. My new pain doc gave me the trial pack of Savella about 3 weeks ago and it has been fairly rough. . .it does seem to help a lot for my joint pain (esp. knees) but it’s possibly not as good for my leg (muscle) pain.

Savella has definitely given me an improvement over my previous pain levels, however. My problem is that I can only get up to 50 mg. per day; when I step up to the 100 mg. per day, it feels like I’ve been poisoned. . .horrible nausea and a headache, and yesterday morning I was feeling really depressed and anxious. I know it’s the Savella causing this and am hoping that it goes away with time. I really want to continue with Savella because it really helps relieve the pain and it seems to be killing my appetite (which is great because I need to lose 25 lbs.) so if I can stay on it, I think it will help me with the weight loss. If I can deal with the anxiety, I could say that I could really endorse Savella–but everyone is different and needs to judge for themselves.

Good luck and best wishes to everyone trying to deal with chronic pain. Thanks for your comments as they’re really helpful.

May 29, 2010 at 9:56 pm
(136) Karen says:

I am a 39-year-old, diagnosed with fibromyalgia almost 2 years ago. I have been taking Savella for nearly a year now and it has made most of my fibromyalgia symptoms vanish. It is such an amazing drug for me that I wrote a letter to the company. I was able to get off of all of my other drugs due to Savella (at various times I had been on Lyrica, Cymbalta, Ambien, Lunesta, and a variety of muscle relaxers and pain killers). Now I take 200 mg of Savella per day, and some Tramadol (usually one 50 mg/day) and Cyclobenzaprine (usually one to two 10 mg/day). I got fibromyalgia 2 years ago. I had been a well-paid top executive (a senior vice president) in a company before fibro happened. Due to fibro, I had to take an extended leave of absence. I ultimately got laid off, due to the economy, but I think fibromyalgia was partially to blame. I have had to re-arrange my life, as I’m sure most of you have had to do! Wow. I went from being a major achiever to being someone who would get worn out in 10 minutes trying to fix dinner. My short term memory was (and still is) affected, but it has gotten better. And I have begun to successfully do freelance work in a relate field since going on Savella. I do not think I will ever be able to work at the pace I was forcing myself to work at again. But then again, I don’t want to. I never knew that lack of sleep and stress could cause such a terrible syndrome to happen. I would go into more details of how my fibromyalgia, but they are depressing; the first year was terrible, and everyone but my husband thought I had literally lost my last marble. I had friends who thought I just needed to eat right and exercise, and then I had a family member who thought I just needed anti-depressants. I remember a phone conversation with a good friend, an athlete, who said, “I know what you need! Just let me whip you back into shape with exercise!” I hung up and started crying. No one seems to fully understand fibromyalgia unless they have it. Fortunately I have good doctors who do seem to understand it, and they are what saved my life. (Of course, some doctors didn’t get it; they were the ones who thought I was just mentally ill. I no longer see them). I would definitely recommend trying Savella if you have not. I had no side effects, whereas with Lyrica I had mental fogginess. I wish all of the luck to my fellow fibro sufferers.

June 1, 2010 at 2:04 am
(137) Micha Lazos says:

BEST EVER! I got my life back over 99%! I am 25 and have had fibro since I was 14. I was taken off Lyrica and Savella replaced it. I lost over 22 pounds in water weight in less than 14 days. LYRICA MADE ME HUGE! SAVELLA IS MY MIRACLE AND I TELL EVERYONE! AND JESUS OF COURSE!

June 1, 2010 at 7:06 pm
(138) Paula says:

I have been on Savella 200mg per day for a year now and since my auto accident in 2005 and Dr’s having no clue what is wrong, a year ago diagnosed fibromyalgia. Savella has been the best medication I’ve been perscribed in 5 years!!!! I have 24/7 pain in SI joint area (hip area) and I take tramadol and savella and it has reduced pain levels tremendously that I can funtion more w/daily life. I am not depressed, nor ever have been. I am still limited to things like standing so long, bending much etc, I do them but pain increases by next day seriously.. I have NO side effects on Savella, just more funtional days for me.. I have learned this also by purposely missing a day-2days of savella to see how much it really helped with pain and at day 2 it was soooo bad I could hardly do much and couldn’t take it. Pain levels were around 7-8 number daily and on Savella it’s down to about 3. I have tried so many drugs in the 5 years and nothing has worked to reduce pain. I tried Lyrica, had weight gain side effects and couldn’t take, I tried Cymbalta and it didn’t work so then Dr. put me on Savella and wow… wish I had been on it long time ago. I’ve tried narcotics like oxycotin (sp?) and it did absolutely nothing to pain levels so just didn’t take hardly cuz did not help one bit. Bending, standing, sitting are the painful activities to do and w/out Savella I was way more limited. Now I can ride my horse some, go for little walks, etc. The only downside to Savella is after the first 3 months insurance covered it and then decided it was covered, so I have to pay full price for perscription monthly, but that outways the benefits I get from Savella tremendously, especially since don’t have any side effects. I have gone thru medications like water in 5 years and nothing has worked like Savella, and I react to meds so sensitively and have no side effects on it.. It has been a life saver, and don’t know what I’d do w/out it. I just hope sooner than later the insurance decides to cover this perscription again.

June 13, 2010 at 6:40 pm
(139) Janice Falkner says:

I am 65 and have been on savella for 1and1/2 months.
I have had fibro for 17 yrs.I had rotator cuff surgery and
it flared the fibro pain up with unreal musle pain.Combining savella and 5mg valium at night have
been my salvation.I have quality of life i have not had.
I praise God for feeling like a productive woman again.
I pray blessing’s and pain relief for you

June 13, 2010 at 6:49 pm
(140) Janice Falkner says:

I did leave a comment and it did’nt show up.
Thank you, Janice

June 14, 2010 at 2:35 pm
(141) laurie says:

I tried it til day 9 of the pack.I developed blurred vision.I stopped it.All these drugs affect the central nervous system.You cannot stay on them forever.Fibro is forever.Did Cymbalta and it was great but soon stopped working.Savella gave me a sense of well being.If I had stayed on it longer,I could then have assessed if it was helping.I will no
longer try any chemicals.The long term affects of these pharmaceutecals are unknown and they are a temprary fix.Imagine what they do to your liver? I will try holistic things next….

June 17, 2010 at 6:06 pm
(142) Sharon P. says:

I stopped Savella two weeks ago today cold turkey. Not a good idea!!!! Doc wanted me to wean off 1 a day for one week, which I did, then 1 every other day. That seemed to make me feel sick so just stopped completely! Have been on for five months. Beginning felt great – then sleepiness, feeling of not well, set in. Never got past the 12.5 mg as felt worse. Did nothing for pain. Am suffering from withdrawal, chills, sweats, loose stools, no energy, tingling in body. So far, not any real help from doctors. Have no quality of life right now. Two days out of these two weeks I felt absolutely great and thought I was over the worst, then it hits again without warning. Have tried many antidepressants, doctors say anyone with chronic pain is depressed. I personally am fighting that theory. I haven’t felt well on any and for now am refusing them. Anti-anxiety and mental health talking therapy helps the most along with a supportive husband. Anyone who has suffered from withdrawal and has suggestons how to get over this, PLEASE HELP!

June 19, 2010 at 4:33 am
(143) Sherry says:

I’ve been on savella for about 8 months. I couldn’t tolerate 50mg because of nausea and fatigue that didn’t get better with time, plus I had this really sharp vasospasm type of pain in my nose that was unbearable. Everytime I went off the savella it went away. Started using it again at 25mg once the weather warmed up because it does work great on my pain, but the nose thing still happened, though to a lesser extent. Cut down to 12.5 mg and was able to take it fairly regularly though still a problem with nausea. Doc wanted me to try taking 25 twice a day. Have had horrible excessive sweating and feel like my body odor has changed to more like a man’s. Hate it and probably am going to go off the savella. SO frusrated. Doc blows off all symptoms.

June 22, 2010 at 1:14 am
(144) Kim says:

Wow!!! I have taken narcotics since 04 for my pain, not darvocet but lortab, (4x a day) and now I’m on oxycodone, flexeril, anti-inflamatory (forgot name), and started savella. Took savella a week, and quit, because of the nausea. I just started back tonite, because I am in so much pain I really can’t deal with it. Im tired of not being myself, and the pain meds really don’t help my pain all that much. I really hope this helps me.

July 4, 2010 at 12:51 pm
(145) sharon says:

i have been on lyrica for a few years and it definitely helps.the only problem is that i have gained a lot of weight from it.
does savella make you gain weight too

July 8, 2010 at 12:48 pm
(146) Nancy R. says:

I have fibromyalgia along with chronic lymphocystic leukemia. My doctor first tried me on Savilla. I don’t think I have ever been that sick in my life. Passing out, severe stomach issues, missed a week of work which is unheard of for me. I will never take Savilla again! I’m on Lyrica now with no side effects to speak of.

July 11, 2010 at 6:34 pm
(147) mary Gachot says:

I tried Savella- no relief at all only made me dizzy and feeling drugged. Not the result I am searching for

July 11, 2010 at 8:07 pm
(148) Debbie says:

I have been on savella for 2 months now I cannot tell it does anything at all for me but make me sleep and I mean sleep i probably am sleep 18 out of 24 hours a day and sweat so bad inside i want even go outside. I am also on 4 percoset 10/325 i think that is correct and i’m on 10 mg of methodone 3 times a day. The only time I am awake is when I take the percoset and methdone as soon as it wears off i’m knocked out again. I am also bi-polor and take 4 valium 10 mg’s a day dapakote 800 mg at bedtime and seroquel 200 mg before bedtime which i do not like at all. I cannot continue my life sleeping all the time I feel like i have just deserted my kids because i’m never awake unless I take the percosets and methdone it depresses me more sleeping all the time I try to get up but my body just want let me as soon as i set back down i’m out again. I can actually set straight up on my bed and sleep my kids have to come and wake me up to lay down. I was like half asleep half awake the other night and i swear it felt like my soul was leaving my body like part of my body was seperating from me and going into the air of course everybody is laughin at me and telling me that i’m crazy but it really is the truth. But i think the next time i go to the dr i’m going to tell him i don’t want it anymore due to all the sleep that is like having no life at all if i’m sleeping all the time. My pain is unbearable when i wake up in the morning i hurt so bad i cry now that it does seems to help with. But i’m to the point i just don’t know what to do anymore I can’t stand up long enough to even cook my pain is so bad even if i have a regular bowel mmovement i’m screaming in pain. I do wish somebody could find something to help. The way i see it i will be on drugs forever i’ve been on them for about 10 years for being bi-polar and then here comes this which they told me in the beginning was arthritis and gave me injections in the back 4 sets the last set i couldn’t walk for 5 days then they told me that was not the problem that i had fibro. but really i’m on so many drugs it’s hard to tell what works and what doesn’t work. At 50 yrs old i cry because i know this is my life i will be like this forever and this is not a life. But I pray for anybody in this condition for anything that will help them but i am having serious problems dealing with all of this.

July 12, 2010 at 12:07 pm
(149) Laurie says:

I started taking Savella about 2 months ago and I love it. I am chemically sensative, so it has been a struggle to find a medication that will be a benefit instead of a pain because of all the side effects. Side effects to this one (for me anyway) compared to others have been very minimal. I do run a little hotter than normal, but that will be nice once winter comes. This has truely made my life more comfortable. I haven’t had this much energy since I was a child…

July 14, 2010 at 11:09 pm
(150) Michelle says:

I’ve tried Savella last year when it was available as samples given to me by my doctor. It made me very ill. At the time, I was taking a combination of Lyrica and Savella, I had severe headaches, dizziness, fatigue, and nausea, on top of my regular FM symptoms.
I was on Savella for two weeks before I stopped.

August 19, 2010 at 9:59 am
(151) Cindy says:

Heather S – Your story sounds exactly as mine. I too had horrible leg pain as a child. Started around the age of 7 or 8. I would cry myself to sleep at night. My parents never took me to the doctor and my mom just always said it was growing pains. I can remember being at school at my calves hurting so very bad! But at night it was always worse for some reason. Like you, my symptoms became more widespread with age. I’m 38 now and am in so much pain everyday. I’m a very outgoing person that use to love to socialize with friends and family, but now I struggle just getting out of the bed everyday (some days worse than others). Most people have no idea how bad I feel. I know they think i’m just unsocialable. I feel your pain and your not alone. I’ve tried so many medications. Seems like the ones that really work (narcotics) are the ones the doctors don’t want to give. I can understand their thoughts of addiction but I think there is a differance in addiction and dependancy. We depend on our medications to live our lives. Quality of life is very important. I hope a breakthrough in medicine for Fibro is coming soon.

September 11, 2010 at 1:38 pm
(152) Kathy A says:

Heather S. and Cindy – same story with the childhood leg pain. Makes me grateful my daughter hasn’t experienced it; maybe she won’t get FMS. Savella is giving me my life back, but I’m worried about the side effects. Titrated up slowly to 50 mg/1xday and HBP, Sweating, hair thinning, bruising, gum bleeding so doc put me down to 25 mg/1xday. Hope the side effects go away as Savella has given me energy, hope, slightly less pain and less appetite. May just take it until weight gain from other meds is gone.

September 15, 2010 at 12:10 pm
(153) Amy says:

I’ve been on Savella for two weeks now. Was just diagnosed with fibro and have been suffering from debilitating chronic migraines for years. The head pain and fogginess I wake up with is virtually GONE. I haven’t had a migraine in the two weeks, its really amazing. Normally I would be bed ridden for at least two days out of two weeks. The rest of my fibro pain has gone down also and I do seem to have more energy. I take no pain meds and only vitamin supplements. I am 37, slender, healthy and low blood pressure, my only other condition is Hashimoto’s Hypothyriodism which I take a daily dose of Synthriod (88)

However, my side effects so far are:

Face flush and hot
Slight nausea when first started and a little in the morning now
Feel dizzy and lightheaded off and on
Feels like my heart races a little sometimes but I haven’t been back to check if my heart rate has gone up yet or not.
One incident of random rage and one incident of random crying, these aren’t usual for me

BUT I’m willing to stick this out, I see my doc next week. The improvement to my head pain/migraines is like a wonder drug. I would put up with these annoying side effects since its better than the stabbing pain in my head. My head pain was so bad it made my body fibro pain seem weak by comparison. If anything changes I’ll update. I’m a little nervous reading about all the heart problems on different blogs it supposedly causes.

September 20, 2010 at 3:07 pm
(154) Barb says:

Have had upper muscle pain in both arms, and it’s worse when I try to sleep. My doc has also put me on Savella. Have had all the side effects, except the nausea thank God. The pain is not as bad during the day, but of course, I am a little drowsy, and it takes me forever to get ready, especially because of the sweating. Have another 4 days to go and then I will call my doctor. Has anybody had muscle pain in their upper arms?

October 5, 2010 at 12:03 am
(155) Stacy says:

I was on Lyrica for about three yrs until it got to the point where my tongue started being numb, I stayed on it for about 6 mo after that until my throat also started swelling. Now I am taking 90mg. Cymbalta, 100mg Savella, Mirapex for RLS,and Celebrex for arthritis. I have noticed a differents in my pulse, blood pressure and there are times I’m lying down and my heart starts racing. I don’t know if it’s from the Savella or not though. The Savella along with the rest has eased the pain a bit but I am so tired all the time. I also have start sweating perfusely without doing much at all. Why can’t they just find something safe for this pain that will help each and everyone of us ?

October 8, 2010 at 1:38 pm
(156) Adele says:

After many years of intense pain I was diagnosed with FM. Have been a migrain sufferer for 40′s years. Doctor prescribed Savella which almost instantly relieved my pain and eased my headaches but- the sweats and the heat levels that I feel are horrible. It feels like your body is in flames all day long. Decided, that I must deal with the pain then deal with the burning and sweating. If only the company could work that out I would be in love.

Now the doctor changed in to Cymbalta 60mg 2x a day. Not to fond of taking it and not sure how it will affect or not affect my headache situation. Just found out several minutes ago, the insurance only wants to pay for 60mg 1 x a day. Now I need to find out what to do….

October 16, 2010 at 9:48 pm
(157) Martha says:

I noticed that so many of you are concerned about taking an anti-depressant when that’s not your problem–pain is. Recent research shows that the brains of people with FMS are not wired the same as people without it. So, it would stand to reason that something that affects your brain would work toward the root cause of the pain.

Lyrica made my feet swell and I had terrible nightmares. I was on Cymbalta for several years and experienced some relief. I’m planning to start Savella next week, but wanted to give myself a fairly decent break from Cymbalta before I started something new.

Those of you who have expressed an interest in Xyrem, I honestly don’t think you want to go there–even if it gets approval (it was denied two weeks ago). I was given the drug off label for sleep problems, and it is dangerous when combined with other medications.

My doctor wouldn’t give me a narcotic if I was writhing in the floor in front of her from the pain. I am just about ready to give up.

I lived with FMS for 13 years and no one knew I was sick. My thyroid blew and I have never been the same. Since 2006, I have become increasingly unable to do even the simplest of tasks.

It’s hard to keep hope alive.

October 17, 2010 at 3:12 pm
(158) Oz says:

I have been on 100 MG 2x a day now for a few months now, I do believe its effectiveness is wearing off

November 4, 2010 at 10:39 am
(159) Jeanna says:

I have very profound fibromyalgia. I have always been the problem solver and go getter. My life was reduced to my bedroom for almost a year. I also almost lost my life to side effects of fibromyalgia. At one point I was on about 17 medications including flexeril,
Oxaprozin,Neurontin,Opana,Oxycodone,Cymbalta, Lyrica and etc. Lyrica was useless to me, Cymbalta made me suicidal, Opana saved my back. It is a long release narcotic without the side effects of Oxycodone. Savella saved my life. I have been able to get up and go to everyone of my 6 kids activities, I have started tent camping and hiking again, I can keep up my house and just everything I used to do, the bad part for me, and I am hypersensitive to medication, is that the Savella makes me lose my vision. It gets so bad that I can no longer see. The side efect is reversible and I have had to keep lowering the dose to stay on it but even if I have to go off for awhile and back on, the value of my life is worth so much more. Thank you Savella. Oh, I read an old comment about someone not wanting to go on another anti – depressant. This in no way has the effects that drugs like Effexor and Cymbalta have. You will not have all those zaps and other side effects. I don’t notice anything. If you wish to try another effective anti – depressant Pristiq is wonderful. No side effects, works wonderfully and has the great side effect of losing weight. I have lost 40 pounds on it. Whoo hooo, finally one good side effect

November 14, 2010 at 2:01 am
(160) Shirley K Ramsey says:

Savella has been a life saver for me I have been on this med for at least 6 months now and I can use my arms to comb my hair I can get out of bed with out excruciating pain I was on so much pain killers that I have not driven a car since Aug. 2009 I really thought I was doomed and would never be able to get out of bed and live a life without pain the pain killers my nerves are always inflamed and I feel as if my insides are like jell-o. With Savella I am able to get up every morning thank you for this wonderful drug.

November 15, 2010 at 3:03 pm
(161) Cass says:

I am just finishing my first pack of Savella and suspect I wont be starting the next.
Sadly this medication started off great and is finishing poorly for me just like so many other medication. The pain did get somewhat better but the chills and night sweats are unbearable. I am in surgical menopause so I am familiar with these symtpoms but since i have been on estrogen I haven’t had them. This medication has kept me up several nights sweating and freezing. Last night I never got any REM at all.
It sad too because I had so much hope for a non narcotic drug. I agree with someone else, narcotics so far have worked the best the problem is they are horrible on the body too and easy ( for me) to be addicted :( but they last longer in keeping my pain reduced … GAh I hate auto immune diseases ( i also suffered badly with Endometriosis!)
I am happy to hear some are finding relief..

November 19, 2010 at 11:20 pm
(162) Lisa says:

Ive been on Savella for just over two weeks and I have to come off of it. I am flushed, running a fever and feel like I have tonsilitis. The Drs office says thats not possible, but when I titrated down to one pill a day that symptom went away. They swear I was coming down with a cold and UH NO.
That plus I knows its affecting me in mood swings and I have a 5 eyar old. I am triyng NOT to beat her bum every time she doesnt listen to me, but I am getting p*****d over everything. I am so done with that. I cant treat her like that and I cant be McB****y to everyone I come in contact with!!

March 14, 2011 at 9:55 pm
(163) Rachel says:

I had similar symptoms, but was unable to find them while looking at the side effects. I had a sore throat and somewhat of a stuffy nose, but it just didn’t feel like a typical cold. Even the inside of my nose became excessively dry and cracked to the point of being sore and bleeding.
I have decided to wean myself off so we’ll see what happens!

November 20, 2010 at 12:36 pm
(164) Dee says:

I started Savella a little over two months ago but, sadly, I am weaning off of it. Though it took away my pain almost completely, the side effects are intolerable.

I did have a tiny bit of nausea at first (which seems to be the most common complaint from Savella users), but that was not an issue for me. Unfortunately, I ended up with almost every other side effect listed – extremely intense and uncomfortable hot flashes, insomnia, palpitations, fast heart rate, and high blood pressure. The high blood pressure was the last straw. My normal BP is always around 120/80, but while on Savella it rocketed to 154/90.

I’m disappointed that I had to quit taking Savella, as I felt better (pain-wise) than I have in years. However, after seeing my blood pressure rise, I chose to discontinue taking it because the pain from the fibro won’t kill me but the high blood pressure and heart symptoms can.

FYI – I am weaning off Savella by cutting my dose in half for a week, then taking 1/4 dose for another week. So far, so good (I’m at the end of the first week right now). I’ve heard absolute horror stories from people weaning off of Cymbalta and Lyrica, but aside from fibro pain I am not having any of those horrendous withdrawal symptoms.

November 26, 2010 at 5:53 pm
(165) Jody says:

I tried to read thru all the posts but as you all must know, it isn’t easy to pay attention and concentrate for more than about a page or two… I noticed some comments on what people are taking for pain. I was only on T3′s as needed for years and a one month perscription would last me about a year, since I try to keep my meds to the very minimum to function. I first got sick in jan 1998, and wasn’t diagnosed with chronic fatigue syndrome until 2001, and then was also diagnosed with fibro myalgia, along with a sleep over study to explore what me and my dr’s have thought was insomnia for most of my life, but turns out i have advanced phase delayed sleep syndrome, and terrible chemical sensitivity disorder…. that one probably causes me more illness, nauseau, headaches, and all over feeling horrible than any of the others combined… i can tell what chemicals are present just by the taste the comes out of my tongue… and can’t get down the laundry detergent isle without becoming so sick i won’t be able to check out of the grocery store… i just have to get out and get fresh air. I have thrombosis that hasn’t ever gone away, since i was first diagnosed in mexico in 2006. I always had normal to low blood pressure, and now it’s high. I feel like i have mini strokes often. Dizzy, imbalances, throbbing in my large blood vessels, numbness and tingling in my arms and legs, vision is weird, different, but hard to explain, and it’s no wonder that anxiety and panic attacks become something to try to keep under control with whatever methods I’ve learned so far. In the past year, pain has been so great that at times i went to emergency and had to be assisted or carried because i couldn’t even walk… emergency dr’s are usually strangers to me, and it’s always someone different. The first time in a series of about 6 trips in 3 months for pain, the dr told me I should be on oxycontins. I told her absolutely not… i have a friend who has been on methadone and oxy’s in the past, and he has told me they are no different and very addictive. i also have a friend, who i don’t spend time with who i’ve watched flash oxy’s off of tin foil, but he says he can’t manage or bare his pain without them… and i guess i feel sorry for him, but the few times i was around, and watched him fade off into what looked like a peaceful pain free place, but reminded me too much of what i’ve seen on tv to people taking heroin, it scares the begeebers out of me that a dr would recommend something like that. Also my pal who used to take them, told me the main reason he stopped and moved to a small town was that he had people try to break in to his house one night, because they found out he had them… he told me he truly believed they would kill him to get his meds. i believe him… and as a single woman, who lives alone, that’s the reason i told this dr that i couldn’t have them… even if it was only due to fear of break ins, for theft, and my own endangerment. The next dr, gave me 6 toradol to take home with me which i thought worked great. If one didn’t, i’d take a second 4 hours later, and was quite surprised by how good i felt and energetic, and realized it was because i wasn’t in so much pain… so i went to my family dr to get a perscription for them, and instead he gave me lyrica free samples and a perscription for tramacet. Then a warning, which was re-iterated by my pharmacist… “if you find yourself talking a lot really fast, and sweating, and nervous, with more than usually anxiety, get to a dr or hospital immediately. Well the first day, i thought i was going out of my mind, sweating profusely, anxiety and nervous like crazy… and honestly don’t understand why he gave me them, rather than the toradol that i asked for. anyways, i have the toradol and take it like i did the T3′s. It’s been 4 or 5 months and i still have the same bottle i was perscribed for one month… even tho my dr keeps saying just take one 3 times a day, every day… i don’t feel that’s the right thing to do… I have nurse friends who are older and one was my reflexologist for a while… she talked a lot especially about when her mother passed away, and was on self administered demoral or morphine, and then said to me, “you know those drugs are really just another form of euthenasia”. I was bedazzled… “what?” dr’s know this? she said of course they do, but when a person is very old and is dying of natural old age, what is the harm if the drugs help them feel more comfortable in their last weeks or months? I can see and understand that… but I’m 46. And I don’t think i’m terminal yet… but if dr’s know these related drugs cause euthenasia, why would a dr tell me to take them every day, 3 times a day. I feel so often that i’m nothing but a burden patient to dr’s. My complaints are too numerous to address, I have too many problems, and over time, is only getting worse. i have to have no more than 2 issues to discuss with my dr’s at any appointment… 2 and no more. Well… I still have a broken bone in my foot that’s never been taken care of… a let and knee that suddenly swelled up and became terribly painful like torn ligaments but i didn’t injure it, but kept falling down badly, because i couldn’t put weight on it, and would lose my balance and all strength in that leg if i wasn’t really careful… I fell down a full length of stairs twice, fell off my deck, would trip over every day things like the vaccuum, but couldn’t catch my balance and fell hard… usually injuring myself but not as badly as i knew it could have been… I had a previous similar type of pain in the ankle of my other leg a few years earlier and like this knee nothing shows up on x-rays, bone scans, etc… dr’s can’t explain it, no evidence of an injury, but so painful, i can’t walk. A cortisone shot finally was the delightful 5 minute needle in my ankle that completely took that pain away… but suddenly in the same moment, the pain in my right arm and chronic pain in my back became noticeable… i hadn’t even noticed them as long as i had that terrible pain in my ankle… i didn’t complain about them as much as i had in the years before… haha. everything is relative isn’t it.
Anyways, if anyone kindly read all of this and has any suggestions for me, I particularily need a new family dr, and/or specialist in Edmonton AB. I moved here in March and don’t have a dr. Also, 2 and a half years ago, i began putting on weight, fast, and different than ever before… i could swear i’m pregnant, but i think i would have given birth by now. the weight is mostly and to me grossly and suddenly so much so fast, in the front torso… boobs and belly have just grown almost like I’m being blown up like a balloon… i’m having trouble breathing, when i eat anything, my stomach becomes distended and i’m very uncomfortable, and it doesn’t go away… in fact, sits sometimes so long i become nauseaus, or have little upchucks, and can spit into a large glass, filling it almost every night… it’s horrible…
I’ve wondered if there is a correlation with the sudden high blood pressure, the thrombosis, the pain medication, menopause, or maybe a tapeworm that must be a few miles long now and only growing… i feel so depleted, and am sure i’m not getting the nutrition out of my food… i had a hard time keeping weight on for the 5 or 6 years prior, and had to make myself eat high calorie foods at bedtime, just to keep my weight at a certain level or i looked like a skeleton with skin and would begin looking jaundiced if my weight fell too low… i didn’t change anything when this weight gain started… but have noticed that this year, it seems i’m always hungry… i wake up in every few hours even in the night, and feel like i need something to eat… and the weight is still coming on fast… i can’t dress, because i outgrow my clothes too fast… i’ve put on weight before, but this is only comparable to pregnancy weight gain, boobs that i can’t figure out what bras to buy, and even if one fits in the morning, i feel like i have a saddle on by afternoon and it hurts unless i take it off… and it makes it hard to breath… i still look fairly slim because of my height and the weight is only in my torso… i can’t do the bottom up on my pants but they fit everywhere else, and i have humungus bossoms… i haven’t had my blood sugar tested for a little while but it’s always been normal and i don’t eat sugar. I am snacker, i eat healthy whole foods, and in small portions and no matter what i do to try to lose a bit of weight it keeps coming on, I could say, daily… i feel like a gain a quarter pound a day, that never goes away… I have regular bm’s, unless i’m sick, as always, then it’s 10 trips a day and a bath to stop the burning haha.. and one more thing… i’ve noticed that when i get the urge to pass water, it becomes urgent immediately, so much so that I can barely make it to the washroom, within seconds of having the initial urge to go. When i am active for instance, get in the mode to clean house, or do some project that has been put off for so long due to fatigue, I find myself sweating terribly instantly… i’ve never sweat like this ever in my life… even pre disability… on a stair climber for 40 minutes… this is so new and bizarre to me… any one have any ideas, or similar experiences, and can share some info before i see a dr… i don’t find dr’s really know or try to really look into my complaints… the last tests i had, the dr said i was’t showing any signs of entering menopause… haven’t had anything but perfect blood insulin tests usually 4.5, but always had excellent blood pressure, or low if anything… and now one test was in the high range. I plan to go test it two more times this week to see if it was a one time incident or if i need to go see a dr about it. i just don’t have a dr. haha i know high blood pressure isn’t good. thank you for letting me have this outlet to tell someone my complaints of late… even if no one reads this, or i get told to go and read all the comments, the answers are all there… lol…. I’ll try, but my own self care seems to be in the back seat most of the time… i just came across this site about a month ago and decided to subscribe. This is the second email i’ve recieved and decided today, would be the only email i read, or write…
i hope i get a notification if someone does respond. i don’t know if i’m allowed to give my email address… sorry, please forgive me if i’m not supposed to… i’ll risk it for any help jody_f@live.ca
i won’t get arrested or kicked out will I? :)
my compassion and heart go out to all of us, and our invisible silent suffering… we aren’t crazy, we’re nuts. haha we’re not lazy, we just can’t seem to figure out how to clean a room we’ve cleaned a thousand times, or why we’re in a room and can’t remember what we went there for, or why we keep remembering our appoints the day after… and know we need 5 things to take with us before we walk out the door, but what are they? I do understand what the “dis” in disability means… i feel better just being here… thanks to all of you… god bless, and a wise person said these words that made a world of difference to me when i was at my lowest, accepting my “condition” finally, but is so much dispair about what that meant for my future, thinking it’s gone, i’ll never do the things i had planned… then unexpectedly heard “don’t paint your disability into your future, and maybe it won’t be there when you get there”.

February 5, 2011 at 6:45 pm
(166) WB says:

I have been on Savella since Sept 2009. I’m on 100 mg daily (50 in am – 50 in pm). I was diagnosed with FMS in 1998. Also I had a spinal fusion at the L5/S1 level in 2006 which was successful but I already had permanent nerve damage that affects my right leg. Savella worked in the beginning. In fact all I was taking was Savella and Skelaxin when needed. I suffer from migraines but they’re hormonal and not Savella related. I take nasal Imitrex for that. I started to notice the Savella helping less and less after about 11 months. We added Requip for the RLS and have tried other “old school” muscles relaxants for horrible arm/neck pain. My blood pressure rose significantly when I started the Savella, but since it was working we just added a BP drug since the benefits were outweighing the risks. I didn’t have any major issues when starting the drug. I did the titration pack as directed. I’ve been on Cymbalta (HORRIBLE side effects when I started it and had to stop after 3 weeks), Lyrica (30+lb weight gain), Elavil (just stopped working) plus every NSAID known to mankind. Used Ultram for a while but that stopped working too. I want off Savella and am seeing the Rheumatologist on Tuesday to state such. In fact, I want off all the meds. Requip (2 mg at bedtime) isn’t working anymore and the “zaps” that are going on with my legs are literally keeping me up all but maybe an hour a night. Sleep disturbance has always been an issue for me and NOTHING has worked. My hope is that my withdrawal symptons don’t drive me off the deep end because I’m already pretty close :-) , but I’ll make sure to update this site (if I remember since I can’t remember crap).

February 14, 2011 at 9:05 pm
(167) jkb says:

I started savella and after about 5 weeks I was hospitalized for palpatations and increased heart rate. It really helped the pain but I am no longer taking it.

March 5, 2011 at 9:21 pm
(168) WB says:

Well I remembered to post after I stopped Savella. Withdrawal SUCKED and still isn’t completely over. The leg ‘zaps’ are horrific. More headaches than normal and NO sleep. My doctor has pretty much given up on me I think. I’m off Requip but the RLS was SO severe that we had to try Mirapex. It didn’t work either. Now he has me taking Xanax at bedtime and again NOTHING. I give up…call Uncle…throw in the towel, etc. If this is what my life is going to be like then I can only hope to have an unfortunate accident that ends it all…and don’t worry…all that Catholic school taught me the consequences of suicide so it’s not an option…I can only pray for divine intervention. Good luck to all I hope your struggles get better.

March 14, 2011 at 9:47 pm
(169) Rachel says:

Started on Savella over a month ago for Fibro. A few days ago started with the 100mg dosage and am having non stop palpitations, anxiety, and feeling very restless. The pain has diminished only a fraction and not worth the side effects. I have also been experiencing constipation, insomnia, sweating/night sweats, excessive dry mouth.
I have been on tramadol for years and it has helped to the point where the pain is tolerable. But it seems that most doctors these days are straying from pain meds an are prescribing these meds they know little about and have horrible side effects. I have genetic HBP and I don’t understand why Savella was prescribed to me, since one of the side effects is hypertension and increased heart rate.
I really do hope that people are getting relief from this medication only because I know what its like to be in pain, but I have decided to wean myself off and find a doctor that will listen to ME and treat ME not the disorder.

March 30, 2011 at 8:22 am
(170) Kellie says:

I have had Fibro for 15 years i also have MS (have had this for 5 years), I have 3 bulged disc in my lower back, 1 bulged disc in my neck area, and severe degenerative disc disease, so i am in pain constantly , I take percocet 7.5-325 , 3 times a day this dulls the pain in my back area , except for the neck area, it hurts so bad that i go to the chiropractor once a week for relief , so when the Doctor suggest Savella i gave it a try, because i took cymbalta before and the side effects were hell and i also took lyrica for years in the past but it adds weight on bad!! The savella did help the pain so it was tolerable ,BUT the side effects were horrible for me, Nausea and throwing up so i don’t know whats worse , But
i am going to give the Savella another try because i can’t deal with this neck pain!!

April 4, 2011 at 11:13 pm
(171) Steve says:

Taking Savella now for 3 weeks via titration route. Up to 50 mg twice/day now. Blood pressure and heart rate are elevated (138/88 today). Pain relief thus far is not significant. My doctor believes I’ll need to get up to 100 mg dose in order to get maximum relief. Not sure if the hypertension, fogginess, and anxious feeling all the time is worth it.

September 19, 2011 at 2:31 am
(172) Julie says:

Exactly my symptoms. I’ve been on it 1 week. Had to back down to 25mg/day due to anxiety, BP up and HR up to 122. Still have the same feelings, just not as intense. Did you get any better and are you still on it?

April 12, 2011 at 1:35 pm
(173) Kellie says:

Well i gave up the Savella, my blood pressure went to the sky, 160/ 105 … and i did not think the pain relief was worth it. So i am taking percocet 3 times a day with celebrex twice a day , and Lyrica twice a day, and the most important part that i am doing is Exercise , yes it’s hard but i have so many health issues that if i just lay around i am not helping my body at all, i have to keep moving even on days i hurt so bad that all i feel like doing is dying, i know if i give up and lay around i hurt worse, key to getting relief is keeping your body limbered up and moving. Best of luck to everyone with any type of pain issues, i do feel your pain!!

July 2, 2011 at 10:14 pm
(174) Lee says:

I’ve been on Savella for about 2 months. Very slowing bringing up doseage since I tend to have signifiicant reactions on low doseage’s of any meds. So far I am amazed that the intensity of my daily headaches has reduced. Nothing I’ve taken before has done this…what a relief. I’m not sure it helps me sleep although not having the pain from the headaches does make it seem like I sleep better…at least in part. I still have extreme pain in joints and muscles, so my Dr. started me on flexeril and tramadol. I’m concerned with everything I’ve read about mixing these 2 drugs. I’m starting off slowly with the flexeril, 1 5mg at night with 50 mg Savella (2nd dose for the day) and am holding off on the Tramadol until I know the effects of what I’m already taking. Has anyone else done this combination?

July 20, 2011 at 9:16 am
(175) Rachel says:

I am on the starter pack of Savella that my dr gave me. The first week I had to wean off the Effexor I was on, which was horrible, as well as increase the Savella. By the end of the week, I was able to uncurl myself from that ball of pain and do something! My overall mood has gotten so much better! I really feel better than I have in years! Part of the whole picture is that the pain is already almost gone. I had a couple of days where I just stopped doing something and realized I didnt hurt, and had a good happy cry about it! I have tried Cymbalta and Lyrica and couldnt take either. I think the key is the titration pack that has you gradually work the daily dosage up. I heartily recommend anyone with FMS or CFS to give it a try! So far its been a miracle!

August 10, 2011 at 4:03 am
(176) Linda says:

WOW, after reading all of these posts about Savella, not sure if I should start or not. Been on cocktail of drugs for years. Was originally diagnosed in 92 but nobody really recognized fibro so no effective drugs. Progressively gotten worse, and since 2004 been diagnosed with Chronic Lymphocytic Leukemia. I tried methotrexate and worked great but screwed my liver enzymes up (I have fatty liver too along with many other illnesses), so I had to stop. I hope Savella doesn’t do this too. I’m worried because I, too, have high blood pressure (being treated) and high cholesterol (being treated). I’m also very overweight and some of this medication is not helping at all. Not sure what to do, but would like to try Savella. Dr. said it may take 2 months for the nausea and flushing to be over but to stick with it, because they’ve had great success with it. Ugh! What to do???

November 2, 2011 at 4:49 pm
(177) paul Farinella says:

I was prescribed Savella for severe Allodynia Neuropathy, which covers my legs, arms, hands, back, face, and neck. It is a burning yet cool pain, similar to extremely intense Noxema covering your body. It is disabling, and I’ve had it for 17 years. Can not ware clothes, go outside, take a shower, or do anything without burning my skin.

Savella was supposed to work, but actually made the pain worse. After two months, I had absolutely no response to the drug. In fact, I developed prostate problems which is painful and alarming. Urinating is very difficult, and I always have prostate pain on top of the Allodynia. I’m far worse off for having taken Savella than had I not. I am completely disabled because of it!

November 3, 2011 at 9:27 am
(178) Lisa says:

Savella has been a life saver for me. Works better than pain medicine. Have had Fibromyalgia for at least 10 years and spent many of those off work and in the bed, and in severe pain. Was sick of it and sick of Drs. offices and medicine. I am an RN and tried everything I could find. Am better now than I ever was, back at work, not tired, not hurting. This is a miracle drug for me. Takes 3-4 weeks to work and made me a little nauseated for a while. And did I mention I lost 25 lbs.? Had read about it while I was bedridden and looking for a cure, it wasn’t even on the market yet. Thank you Savella you saved my life. Would like to personally thank all involved in bringing this drug to fruition!

November 3, 2011 at 9:40 am
(179) Lisa M. says:

Savella has saved my life, Fibromyalgia for 10 plus years and off work and bedridden for 7. I am an RN, and Savella saved my life. Feel better now than I did when i didnt have Fibro., not tired or hurting anymore. Was depressed and suicidal felt useless and hopeless. Scoured the internet looking for help, been to more Drs. and taken more medicine (Rx. and over the counter than I can remember). Read about milnaciprin in clinical trials and it sounded promising. Forgot about it until my Nurse Practitioner mentioned a new drug for Fibro., waas on Lortabs and flexeril and minor relief. Taking Savella now for about 6 months, no pain meds. no muscle relaxers, knots in neck and shoulders gone. Not tired anymore, back at work, life is better than ever. Thanks to everyone that brought Savella to the market. And no I’m not a Savella rep., just someone with Fibro. that has been to hell and back. Hope this helps someone out there.

November 11, 2011 at 1:08 pm
(180) Julia says:

I have been on Savella now for 5 weeks now including the titration pack. My muscle and joint pain have greatly improved. I was taking 6-8 ibuprophen a day, using heating packs and super hot baths (which helped some) for the pain. I was just diagosed finally with fibromyalgia. The family doc first said it was herniated discs, then osteoarthritis. He recommended an orthopedic doctor for cortisone shots in the spine. I wasn’t comfortable with that so I told him I wanted to go to a rheumotologist instead.

The rheumotologist said it was none of those and it was fibro causing the pain. He said Savella was the only one to try because he warned me about weight gain on the other two, Lyrica and Cymbalta. He said perservere through the side effects. At first there were episodes of sweating and nauseousness. Then the heart beating fast in the chest and my blood pressure rose. It has risen once again to now 138/96 from my previous BP of 120/70-80 average.

I called the family doc who is now taking care of my fibro and he has put me on a BP med to counteract the effects of the Savella. The Savella has helped the pain at greatly except for episodes of what I call “locking up” of the neck causing migraines and the back/hip a couple of days a week and he said to take 1/2 pill of flexeril which promptly causes drowsiness. So I take it in the late afternoon otherwise by the morning, I am still drowsy if I take it at bedtime. By the morning, the muscles have loosened and feel much better. The doc said give the BP medicine a week and if it does not make it go down, I may have to go off Savella.

December 12, 2011 at 11:36 pm
(181) Veryfoggysinglemom says:

I starting having fibro symptoms that progressed when my youngest was 2. That has been about 6 years. I am in a fog every second. I tried Cymbalta, but was even more drowsy and fatigued than I was before it and the fog intensified. I tried Savella for a month, but it gave me intense nausea, so, I went off of it and my rheumatologist decided to treat my RA more at that point because she was very leary of the Lyrica and the fog. A month ago, and still being medicated with the RA medications, she has put me back on the Savella at an even slower pace than before…still get the nausea, but I think it is starting to help with the chronic fatigue and fibrofog. Maybe, it’s a combination of my meds, maybe not, but I will take any amount of ‘better’ I can get with being a single, working mother with these two crippling conditions.

December 19, 2011 at 4:41 pm
(182) Jan says:

Hello, I have been using Savella for over a year now. It definitely helps, but the right dosage is important. I was up to 200 mg per day, but due to high blood pressure issues had to back down to 100 per day.

Remember that while it is used for depression in Europe and elsewhere it works with the neurotransmitters and that is what Fibromyalgia is all about.

Also, if you are having a severe exacerbation it might be pain breaking through the treatment you are feeling and not the drug causing it.

Some of the best nerve pain blockers are antidepressants, too.

Many drugs treat multiple conditions.

January 1, 2012 at 7:49 pm
(183) Andrea says:

I had a terrible reaction to Savella. It gave me migraines, made me tired and did not help my painl I think it is a terrible drug and am hoping my neurosurgeon can help me. The drugs have horrible reactions, do not help my pain, mood or have any positive reactions. I would rather be dead than continue taking SAvella or most of the medicationsl I have an appointment with a neurosurgeon and surgery is preferable to the side effects of most of the medications.I a, hoping that I will be able to have surgery; The ,medications only work a short time and have terrible side effects. I have been taking medications for 4 years and I wouldrather take a chance with surgery than continue to take medications the rest of my life. Some new research on minimally invasive surgery needs to be done as soon as possible. I have been suffering for 4 years with mostly negative results.I hope someone will find a surgical technigue which will work inteqd of medicine.

February 2, 2012 at 12:47 am
(184) Ronda says:

I have been on Savella 6 weeks and I finally have my life back! I had NO side effects. Had been having problems walking because of the pain. Was tested for MS, Lou Gherigs, you name it. All negative. My family physician asked me to try Savella. It’s my understanding that if it works for you… You’ve nailed your diagnosis of Fibromyalgia. That’s all it really works on. With the exception of some back pain I really feel great! This has been a miracle drug for me.
Hope this helps.

March 31, 2012 at 11:18 pm
(185) Rachel says:

Anyone else experience MORE pain while titrating up on Savella?

I remember having the expected nausea and hot flashes in the first 2 months, but those have gone away. I get mild returns occasionally. Each time I also get burning pains all over and some popping ones.

I’ve been on Savella for 10 months now. The only other meds I regularly take are Lunesta and Thyrolar. I also take fish oil.

For a while I’ve been on 75 mg (50mg at night, 25 mg at 3PM) of Savella. Has helped a great deal with pain, I feel much looser, but sleepy all day, nap a great deal, and mentally feel blunted/distant as opposed to alert and chipper as my personality usually is. Also, I’ve become rather irritable. I get the urge to fight in every way, only once I’ve been wronged, then I launch an intolerant tirade, with lots of energy behind it.

I’m “going for broke” now to give Savella the best chance. I hope to get more energy like many others mention. I added 25 mg about 3 days ago, trying to reach the goal of 100mg per day that everyone recommends (so, I’m trying 50 mg at night, 25mg in morn and 25 mg at noon). Now I’m having a big Fibro flare -major aches and pains! Been in tears. I remember going through some hard, but tolerable pains like this when I first used the titration pack.

I imagine Savella is loosening my muscles and the icky lactic acid that’s been tied up in the knots is now able to leach out everywhere, causing the all-over aches and occasional sharp jolts. Appetite is low right now while adjusting too.

i just hope this is a “productive” flare and Savella proves to be the best med for me. I just hope the pain now is due to loosening me up. That thought gives me the hope to stick this out to achieve longer term gains.

Anyone else experience MORE pain while titrating up?

April 2, 2012 at 5:20 pm
(186) julie s says:

My diagnosis is fibromyalgia. I am interested in treating underlying ’cause.’ That said- things that have helped:

Xyrem was great- I took it for about 2 years. First day: pain cut in half and energy level doubled!! Had to increase dose due to tolerence, but never had to go to max.
Caused High BP and constant calf cramps. Discontinued because of insurance issue. titrated down VERY slowly. I would have kept taking, but too expensive. CAUTION: You Can Not Drink Alcohol while taking xyrem.

Cymbalta at max dose helped some. Stopped taking because I could not afford without insurance. No significant effect to stopping.

Changing to an anti-inflammatory eating plan has helped a lot of symptoms. Also taking supplements that treat lyme and other coinfections (per Dr Ken Singleton’s book and Stephen Harrod Buhner’s book).

Opioids did not help at all.

Considering Savella.

Anyone with fibromyalgia symptoms should watch 2 videos:
UNDER OUR SKIN (about lyme disease)
DR TERRY WAHLS (talk about curing her MS via mitochondrial support- mostly food) it’s on You Tube.

August 22, 2012 at 10:22 am
(187) Cathy says:

I have been on Savella for 5 months, I don’t like it I sweat all the time and that sucks very much interferes with my job. Besides the sweating, it makes my blood pressure high and never had any trouble before, it makes my blood sugar very high and I don’t like that either. I want to work at getting off of this drug. It never helped with the pain, my pain is still very bad. So why take something that has so many side effect. I am sick at my stomach most of the time, and all very sleepy. I would say be care if you get on this drug. I think the side effect is worst than the pain…

October 7, 2012 at 7:43 pm
(188) Lecia says:

Savella is the worst medication I have ever taken. Cymbalta worked wonderful. It had it’s side effects, but they were worth it because I was pain free. Insurance refuses to pay for Cymbalta because I had not tried Savella. With Savella I have all the side effects that I had with Cymbalta, such as hot flashes, sweating and insomnia, but in addition Savella causes terrible nausea and headache and it does nothing for the pain. It’s supposed to be taken twice daily and it makes me so sleepy I can hardly function. I have to start weaning myself off of this as it’s worthless.

January 12, 2013 at 9:52 pm
(189) Nancy says:

I am taking Savella 50mg twice a day. This us my third time trying this med for Fibro. The other times I stopped because the hot flashes were so bad. I started back again out of desperation , I’ve had such severe pain and fatigue which brought on depression and I’m allergic to Cymbalta and Lyrica. I decided to go very SLOW with the two week titration pack. I took almost a full month before leveling out to the dosage I am currently taking. I feel line I am getting some quality of life back. I have flushes but they are not as severe as previous times. I will continue the dosage I’m on unless I feel like its not enough anymore. I am being closely monitored by my dr whom wants to increase me to 100mg twice a day,( I won’t do that yet since I feel my body needs longer to acclimate ). I hope thus helps someone that is reading reviews. I know I have been helped by reviews I’ve read. Fibro is a real condition that changes lives. I am a nurse , unable to work right now but hopefully I will again. Please don’t give up. Gentle hugs(((**)))

January 30, 2013 at 3:41 pm
(190) sheri says:

Savella is the worst drug I’ve ever taken. Fast heart rate, palpitations, high blood pressure, hot flushes that severely interrupted my sleep, terrible headaches, cessation of menstruation, constipation, sexual problems, severe weakness, blurred vision. did improve pain and mood a bit but went off of it.

March 13, 2013 at 8:12 pm
(191) Karen says:

I have been on Savella for almost 2 months. I am still on 25mg twice a day. I have had some side effects, nightmares, Gastric reflux, headaches and constipation. All are gone except the constipation. I have been on Cymbalta for a year, it is great as an antidepressant but did nothing for pain. The Savella is great, I feel better than I have in years. I didn’t realize how bad I did feel until I started feeling good. I have always bruised easy and do notice more bruises that I don’t recall how I got. I pray this medicine continues working on me because I can’t go back to feeling bad. I did start feeling warmer and sweating easily, but since I spent my whole life freezing I am liking being warm and the sweating is not too bad.

April 25, 2013 at 7:28 pm
(192) Vicki says:

I started the trial pack two weeks ago for severe fibromyalgia pain and insomnia and am on my last dose today. The pain has worsened and the insomnia has worsened as well. Along with that I now have hot flashes all day long leaving me wet with sweat at work and in bed. Also my blood sugar levels have risen as a result of this drug. My doctor has yet to get back to me as to what to do next and that scares me from reading what side effects can happen when you stop taking savella all at once. I just want something to pleas help me! I need my sleep to be able to work at my best and I need the pain to subside to help me sleep and function day to day. I wasn’t depressed before this but now I feel hopeless that nothing will ever help me.

May 20, 2013 at 6:11 pm
(193) julie says:

What about seizures???
I have Fibromyalgia. I used to use Lyrica but that was just a bandaid to the pain. The main thing is that is brought on seizures. I have Epilepsy so they were pretty bad. I went off that ASAP. I have tried Cymbalta. No seizures but I slept all the time – hard for others to wake me up, had hallucinations. I went off this drug. NEVER RECOMMEND.
Now I am trying Savella. It has some effect on the pain but there are numerous side effects: small seizures, tingling legs, dizziness, bad headaches, hot flashes, increased pulse, increased panic attacks and increased fatigue. Also, increased confusion and trouble talking.

This while still on the sample pack. Is the drug worth it?

August 8, 2013 at 8:37 am
(194) Jessie says:

As with any medicine each person has different reactions some medicine helps some but not others. I’ve been on savella for 6 months. The first 3 weeks was hard for me couldn’t sleep upset stomach nausea, night sweets. Then after 3 weeks those symptoms went away and the pain has supsided unless I over do it. I still have a problem with reaching over my head for a period of times also 80 degrees out and wow I would feel like a 100 but to be able to enjoy what life has to offer I will stay on savella. Hope this helps someone decided. God bless

March 27, 2014 at 6:45 am
(195) mobile games says:

Hmm it appears like your blog ate my first comment (it was super long)
so I guess I’ll just sum it up what I wrote and say, I’m
thoroughly enjoying your blog. I as well am an aspiring blog writer but I’m still
new to the whole thing. Do you have any tips and hints for first-time blog
writers? I’d definitely appreciate it.

March 30, 2014 at 9:09 am
(196) alley says:

I have just started sevella it seems to help but i still have the pain never competly leaves. I tryed cymbelta first. It took away the pain my mood was good but guts couldnt take it. Going to pain Dr cause i have intercostal neaurtis also. I guess i will wait and see what comes of this. Hope you all find the right mix as i search for mine.

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