In a study published in The International Journal of Clinical and Experimental Medicine, researchers say they've proven dysfunction in mitochondria linked to the production of energy through adenosine triphosphate (ATP). They say the severity of dysfunction reliably predicts the severity of the condition. In addition, they say tests can distinguish between the fatigue and lack of energy associated with ME/CFS and fatigue caused by other factors, such as sleep disorders or nutritional or hormonal deficiencies.
Much of the controversy surrounding ME/CFS stems from the lack of objective diagnostic tests, which leads some people to believe that nothing is physically wrong with people who have the condition. It also can lead to misdiagnoses. A reliable, widely accepted diagnostic test would validate the illness, reduce misdiagnoses, and possibly make it easier for people with ME/CFS to get special accommodations at work and qualify for Social Security disability insurance.
This study also could lead to treatments targeting mitochondrial dysfunction. For more on this research, including one researcher's recommended treatment for mitrochondrial dysfunction, visit Dr. Sarah Myhill's website.