Genetic Mutation May Help Cause Seasonal Affective Disorder

NEWSBRIEF: Seasonal affective disorder (SAD) may be at least partially caused by a genetic mutation in the eye that makes you less sensitive to light, according to research published in the Journal of Affective Disorders. SAD is more common in people with fibromyalgia or chronic fatigue syndrome than it is in the general population.

The researchers discovered that people with a mutation in a gene called melanopsin (a type of pigment in the retina that changes when hit by light) are far more likely to develop SAD. Melanopsin isn't involved in vision but is part of the structures in the eye that deal with non-visual responses, including control of circadian rhythms, hormones, alertness and sleep.

The mutation may result in an irregular response to light, thereby leading to SAD. Researchers say this discovery could lead to improved treatments and possibly testing for SAD.

Related Content: Symptoms of Seasonal Affective Disorder; Read More on the Study (free registration required)